Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Lauerer, Markus; Bussas, Matthias; Pongratz, Viola; Berthele, Achim; Kirschke, Jan S.; Wiestler, Benedikt; Zimmer, Claus; Hemmer, Bernhard; Mühlau, Mark

doi:10.1002/acn3.51700

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“…The chronic and progressive inflammation of myelin and nerve fibers results in continuing brain volume loss. A large (600 patients) retrospective cohort study showed that percentage brain volume change mainly reveals the loss of white and cortical gray matter [ 6 ]. Simultaneous volumetric analysis shows that in patients with multiple sclerosis, choroid plexuses are substantially bigger than healthy controls [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Choroid Plexus Volume Change—A Candidate for a New Radiological Marker of MS Progression

et al. 2023

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(1) Background: Multiple sclerosis (MS) is an auto-immune, chronic, neuroinflammatory, demyelinating disease that affects mainly young patients. This progressive inflammatory process causes the chronic loss of brain tissue and results in a deterioration in quality of life. To monitor neuroinflammatory process activity and predict the further development of disease, it is necessary to find a suitable biomarker that could easily be used. In this research, we verify the usability of choroid plexus (CP) volume, a new MS biomarker, in the monitoring of the progression of multiple sclerosis disease. (2) Methods: A single-center, prospective study with three groups of patients was conducted based on the following groups: MS patients who received experimental cellular therapy (Treg), treatment-naïve MS patients and healthy controls. (3) Results: This study concludes that there is a correlation between the CPV/TIV (choroid plexus/total intracranial volume) ratio and the progress of multiple sclerosis disease—patients with MS (MS + Treg) had larger volumes of choroid plexuses. CPV/TIV ratios in MS groups were constantly and significantly growing. In the Treg group, patients with relapses had larger plexuses in comparison to the group with no relapses of MS. A similar correlation was observed for the GD+ group (patients with postcontrast enhancing plaques) compared against the non-GD group (patients without postcontrast enhancing plaques). (4) Conclusion: Choroid plexus volume, due to its immunological function, correlates with the inflammatory process in the central nervous system. We consider it to become a valuable radiological biomarker of MS activity.

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Section: Introductionmentioning

confidence: 99%