Percentage of the population at high risk of osteoporotic fracture in South Korea: analysis of the 2010 Fifth Korean National Health and Nutrition Examination survey data

Kim, J. W.; Jeon, Young-Jee; Baek, Dahyun; Kim, T. N.; Chang, Jae Suk

doi:10.1007/s00198-013-2595-z

Cited by 22 publications

(12 citation statements)

References 17 publications

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“…We also observed that when the same age groups were compared, the Ca/P ratio increased in favour of Ca at advanced ages. While these results are similar to those of Kim et al [20] and Maharlouei et al [27], they contradict the results of Basle et al [1]. The reason for this inconsistency may be because Basle et al [1] studied a broad age interval including ages from 31 to 87.…”

Section: Discussionsupporting

confidence: 70%

Assessment of femoral neck fractures in the elderly with respect to morphology and mineral density

et al. 2016

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Section: Discussionsupporting

confidence: 70%

Assessment of femoral neck fractures in the elderly with respect to morphology and mineral density

et al. 2016

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“…According to data from the fifth Korean National Health and Nutrition Examination survey (KNHANES) in 2010, the percentages of the population with osteoporosis among elderly men and women aged over 65 years were 15.2% and 57.7%, respectively [17]. In Korea, the prevalence of osteoporotic fractures is increasing with the rapid growth in the elderly population [18, 19].…”

Section: Discussionmentioning

confidence: 99%

Low Normal TSH levels are Associated with Impaired BMD and Hip Geometry in the Elderly

Lee¹,

Kim²,

Lee³

et al. 2016

Aging and disease

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Subclinical hyperthyroidism is known to be associated with the risk of fractures in elderly people. However, there are few studies assessing whether low normal thyroid-stimulating hormone (TSH) levels affect bone density and geometry. Here, we aimed to assess the influence of the TSH level on bone mineral density (BMD) and geometry in elderly euthyroid subjects. This was a cross-sectional cohort study. A total of 343 men and 674 women with euthyroidism were included and analyzed separately. The subjects were divided into tertiles based on the serum TSH level. The BMD and geometry were measured using dual-energy X-ray absorptiometry and a hip structural analysis program. Multiple regression analysis was used to compute the odds ratios of osteoporosis in the lower TSH tertile group and the association between geometry parameters and the TSH level. We found that the femoral neck and total hip BMDs were lower in the lower TSH tertile group. In women, the cross-sectional area and cortical thickness of the femur were negatively associated with the TSH level in all three regions (the narrow neck, intertrochanter, and femoral shaft); however, in men, these geometry parameters were significantly associated with the TSH level only in the intertrochanter region. The buckling ratio, a bone geometry parameter representing cortical instability, was significantly higher in the lower TSH tertile group in all three regions in women, but not in men. Our results indicated that lower TSH levels in the euthyroid range are related to lower BMD and weaker femoral structure in elderly women.Key words: TSH, euthyroidism, elderly people, bone density, bone geometry Maintaining normal thyroid function is important for achieving appropriate bone development and peak bone mass in young age, as well as for regulating the rate of bone turnover in adults [1]. It is well known that bone mineralization is reduced and that the rate of bone turnover is increased in thyrotoxicosis [1][2][3], leading to an increased risk of hip fractures [4,5]. Bauer et al. showed an association between low thyroid-stimulating hormone (TSH) levels and hip fractures in subclinical hyperthyroidism [6] and a recent meta-analysis [7] revealed increased fracture risk in cases of subclinical hyperthyroidism. Moreover, Murphy et al. reported that higher free thyroxine (fT4) levels were associated with reduced hip bone mineral density (BMD), even in

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“…The prevalence of osteoporosis and osteoporotic fractures, which are common metabolic conditions associated with aging, is dramatically increasing due to rapidly aging populations in most developing and developed countries. Since osteoporotic fractures not only reduce quality-of-life but also increase medical and health care expenses, this condition imposes a significant healthcare and financial burden [1,2].…”

Section: Introductionmentioning

confidence: 99%

Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls

Kim

Han

Jung

et al. 2021

Korean J Intern Med

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Background/Aims: Despite recent improvements in the quality of life of patients with systemic lupus erythematosus (SLE), osteoporosis, and osteoporotic fractures are one of the major complications of SLE. Furthermore, limited data are available on the incidence and predictor of osteoporotic fractures in Korean patients with SLE. Herein, we aimed to assess the incidence and risk factors for osteoporotic fractures in Korean SLE patients compared to those without SLE. Methods: SLE patients aged ≥ 40 years (n = 10,434; mean age, 51.3 ± 9.1 years; women, 89.7%) were selected from the Korean National Health Insurance Service database, spanning a period from 2008 to 2014. Age-and sex-matched controls (n = 52,170) were randomly sampled in a 5:1 ratio from non-SLE individuals. The primary outcome was the first occurrence of osteoporotic fracture. Results: The incidence of osteoporotic fractures was significantly higher in the SLE patients (19.085 per 1,000 person-years) than in matched controls (6.530 per 1,000 person-years). According to the multivariable Cox proportional analysis, patients with SLE exhibited a higher osteoporotic fracture rate than the control group (hazards ratio, 2.964; 95% confidence interval, 2.754 to 3.188), even after adjustment for confounding variables. In the subgroup analysis, male SLE patients or SLE patients aged 40 to 65 years were associated with a higher osteoporotic fracture rate than women SLE patients or SLE patients aged ≥ 65 years, respectively. Conclusions: We found a 2.964-fold increased risk of osteoporotic fracture in SLE patients compared to age-and sex-matched non-SLE controls. Male or middle-aged SLE patients had a relatively higher fracture risk among patients with SLE.

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Percentage of the population at high risk of osteoporotic fracture in South Korea: analysis of the 2010 Fifth Korean National Health and Nutrition Examination survey data

Abstract: As a very large percentage of the South Korean postmenopausal population has osteoporosis or high-risk osteopenia, greater effort at identifying and treating this population should be expended to prevent osteoporotic fracture.

Cited by 22 publications

References 17 publications

Assessment of femoral neck fractures in the elderly with respect to morphology and mineral density

Assessment of femoral neck fractures in the elderly with respect to morphology and mineral density

Low Normal TSH levels are Associated with Impaired BMD and Hip Geometry in the Elderly

Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls

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