Gillen, ZM. Position-specific differences in speed profiles among NFL scouting combine participants. J Strength Cond Res XX(X): 000–000, 2024—This study examined the relationships between speed profiles and athletic performance measurements from the National Football League (NFL) Scouting Combine, and position-specific differences in speed profiles. Subjects included NFL Scouting Combines participants with valid scores for the 40-yard dash, as well as the 10- and 20-yard splits of the 40-yard dash (n = 2,156). Subjects were divided into the following position groups: defensive backs (DBs, n = 421), defensive linemen (DL, n = 356), linebackers (LBs, n = 261), offensive linemen (OL, n = 354), running backs (RBs, n = 217), tight ends (TEs, n = 122), quarterbacks (QBs, n = 108), and wide receivers (WRs, n = 317). Performance measures included 40-yard dash time (with 10- and 20-yard split times), bench press repetitions to failure, vertical jump height, broad jump distance, pro-agility time, and L-cone drill time. The 40-yard dash and its splits calculated v
max
, τ, and a
max
to reflect speed profiles. One-way analysis of variances examined position-related differences. Pearson’s product moment correlation coefficients examined relationships between performance measures and speed profile variables. Skill positions (DB and WR) had the greatest v
max
and a
max
, and lowest τ, followed by big skill positions (LB, RB, TE, QB), followed by DL, then OL with the lowest v
max
and a
max
, and highest τ. For skill and big skill positions, v
max
, τ, and a
max
exhibited greater relationships with combine measures, whereas OL generally had the lowest relationships. The position-specific differences in this study demonstrate potential areas of strength and weakness for certain positions. This may help guide strength and conditioning coaches desiring to improve position-specific speed and acceleration capabilities for American football players.