The phenomena of climate change pose multifaceted challenges to crop and livestock farming, with severe implications on smallholder farmers' income and livelihoods. Climate change has profound implications (economic, environmental, and social) predominantly on rainfed regions in developing countries like India, where agriculture constitutes the backbone of the economy. In this context, the current study analyzes how farmers perceive climate change in the rainfed ecosystem in India, farmers' adaptation strategies, and their major determinants in addressing climate change. Data were collected from 400 sample farmers in South India. Discriminant and multinomial logit models were employed to identify the adaptation strategies of the farmers. It was evident that the factors such as off-farm income, farm income, and farming experience significantly influenced the adaptation strategies for tackling climate change. Furthermore, access to climate change information and literacy level are vital determinants in different climate change adaptation strategies, including crop diversification, integrated farming system, contingency plans for farm operations, and adoption of soil and water conservation techniques. However, the study highlights the increasing role of institutions (government and private) in future to safeguard the interests of farmers by offering a wide range of policy, research, and technology interventions. In a nutshell, R&D focus on climate-resilient agriculture, application of ICTs in agro-advisory services, and creation off-farm employment opportunities for the farmers is crucial to sustaining their livelihoods as these serve as potential mitigation strategies to impart resilience to climate-sensitive sectors like agriculture in rainfed ecosystems in India or any other countries.