Perception of Complex Sounds: Abnormal Pattern of Cortical Activation in Autism

Boddaert, Nathalie; Belin, Pascal; Chabane, Nadia; Poline, Jean‐Baptiste; Barthélémy, Catherine; Mouren-Siméoni, Marie-Christine; Brunelle, Françis; Samson, Yves; Zilbovicius, Mônica

doi:10.1176/appi.ajp.160.11.2057

Cited by 180 publications

(134 citation statements)

References 15 publications

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“…An impairment of this region also could contribute to the language difficulties and consequent communication problems of autistic subjects. 31 GM loss in our ASD patients involved the precuneus that is connected with multiple areas of the interhemispheric cortex, convexity, basal ganglia, and thalami. 32 Changes occurring in this pivotal area are consistent with recent claims that autism is a connectivity disorder.…”

Section: Figmentioning

confidence: 84%

Basal Forebrain Involvement in Low-Functioning Autistic Children: A Voxel-Based Morphometry Study

Riva¹,

Bulgheroni²,

Aquino³

et al. 2011

AJNR Am J Neuroradiol

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Section: Figmentioning

confidence: 84%

Basal Forebrain Involvement in Low-Functioning Autistic Children: A Voxel-Based Morphometry Study

Riva¹,

Bulgheroni²,

Aquino³

et al. 2011

AJNR Am J Neuroradiol

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“…In this regard, a number of electrophysiological and neuroimaging studies reported right hemisphere dominance of auditory processing and speech perception in individuals with ASD, while controls showed left hemisphere dominance (e.g., Boddaert et al 2003;Bruneau et al 1999;Eyler et al 2012;Flagg et al 2005;Müller et al 1998Müller et al , 1999Redcay and Courchesne 2008;Roberts et al 2008; but see Whitehouse and Bishop 2008). Flagg et al (2005), in particular, observed a reversed maturational pattern of lateralization: Whereas controls matured from bilateral activation to left hemisphere dominance in the processing of speech sounds, children with autism matured towards right hemisphere dominance.…”

Section: Introductionmentioning

confidence: 99%

Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

Boets

Verhoeven

Wouters

et al. 2014

J Autism Dev Disord

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We investigated low-level auditory spectral and temporal processing in adolescents with autism spectrum disorder (ASD) and early language delay compared to matched typically developing controls. Auditory measures were designed to target right versus left auditory cortex processing (i.e. frequency discrimination and slow amplitude modulation (AM) detection versus gap-in-noise detection and faster AM detection), and to pinpoint the task and stimulus characteristics underlying putative superior spectral processing in ASD. We observed impaired frequency discrimination in the ASD group and suggestive evidence of poorer temporal resolution as indexed by gapin-noise detection thresholds. These findings question the evidence of enhanced spectral sensitivity in ASD and do not support the hypothesis of superior right and inferior left hemispheric auditory processing in ASD.

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“…Structural and functional neuroimaging studies of language areas have provided evidence that differences in lateralization may underlie language and communication difficulties in individuals with ASD (Bigler et al, 2007;Boddaert et al, 2003;Chandana et al, 2005;Chiron et al, 1995;Flagg et al, 2005;Herbert et al, 2002;. For example, a series of volumetric studies by Herbert and colleagues (Herbert et al, 2002;, demonstrated that brain asymmetry patterns differed in children with high functioning autism compared to controls.…”

Section: Introductionmentioning

confidence: 99%

Atypical functional lateralization of language in autism spectrum disorders

et al. 2008

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Impaired language is a prominent behavioral marker of autism spectrum disorders (ASD), but its neurobiological underpinnings are incompletely understood. We studied letter and category fluency in 14 high functioning ASD individuals and 14 age-matched controls. Each fluency condition was compared to self-paced repetition of the word "nothing." Responses were recorded to monitor performance. In letter fluency, the ASD group had significantly greater activation than controls in the right frontal and right superior temporal lobe. Between-group differences were not observed in left prefrontal cortex. By examining functional asymmetry in frontal cortex, we found that the ASD group had significantly reduced lateralization of activation patterns in letter fluency compared to the controls. In category fluency, no between-group differences in lateralization were found, in light of greater bilateral activation in controls. These findings indicate reduced hemispheric differentiation for certain verbal fluency tasks in ASD, consistent with some previous evidence of atypical functional and structural asymmetries in autism. Abnormal functional organization may contribute to the language impairment seen in ASD.

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Perception of Complex Sounds: Abnormal Pattern of Cortical Activation in Autism

Abstract: These findings suggest that abnormal auditory cortical processing is implicated in the language impairments and the inadequate response to sounds typically seen in autism.

Cited by 180 publications

References 15 publications

Basal Forebrain Involvement in Low-Functioning Autistic Children: A Voxel-Based Morphometry Study

Basal Forebrain Involvement in Low-Functioning Autistic Children: A Voxel-Based Morphometry Study

Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

Atypical functional lateralization of language in autism spectrum disorders

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