Perception of Human Papillomavirus Infection, Cervical Cancer and HPV Vaccination in North Indian Population

Hussain, Showket; Nasare, Vilas; Kumari, Malasha; Sharma, Shashi; Khan, Mohammad Aijaz; Das, Bhudev C.; Bharadwaj, Mausumi

doi:10.1371/journal.pone.0112861

Cited by 59 publications

(60 citation statements)

References 62 publications

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“…Direct comparison of the results of this survey with data of similar published results is complicated by the fact that the methodology vary between studies in terms of characteristics of each population, data collection, and ways of reporting. The level of knowledge is higher than those obtained in 18 to 25-year-old students in Germany which only 13.9% knew that HPV infection is sexually transmitted and <15% knew that HPV infects women and men, 33 in a group aged 18-24 in Singapore only 15.2% had ever heard of HPV, 31 in males aged 12-22 y in India respectively 31.5% and 28% were aware that HPV infection causes genital cancer and of availability of vaccine, 35 in the United Arab Emirates 31% of university students had not heard of HPV infection before, 34 in Hungary among adolescents 12 and 19 y only 35% have heard of the HPV and 46.6% knew that HPV infection may be transmitted by vaginal intercourse, 32 and in the US respectively 38.3% and 33.1% of respondents had heard of HPV and of the vaccine. 16 Not surprising only 4 students in this study have been vaccinated against HPV, but one important observation was that almost 2-thirds were likely to be vaccinated against HPV.…”

Section: Discussionmentioning

confidence: 64%

“…[29][30][31] Unfortunately all these issues among young males have only been studied to a limited extent. [32][33][34][35][36] Specifically in Italy, few studies have been conducted among different groups, [37][38][39] but to the authors' knowledge little is known to date regarding HPV vaccination in young males. It remains imperative this evaluation in order to identify information needs and to design future strategies for expanding cancer prevention.…”

Section: Introductionmentioning

confidence: 99%

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Human papillomavirus infection and vaccination: Knowledge and attitudes among young males in Italy

Napolitano

Liguori

et al. 2016

Human Vaccines & Immunotherapeutics

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This study assessed knowledge and attitudes about Human papillomavirus (HPV) and the relative vaccination and their determinants in a sample of young males. The survey was conducted between January and April 2015 among a sample of 1000 males aged between 14-24 y in the geographic area of Naples and Caserta, Italy. The 54.9% of the participants reported of having heard about the HPV infection. Those who were aware about the availability of the vaccine, who reported the first vaginal sexual encounter before the 18 y and at least at 18 y compared to those who had not had a complete sexual intercourse, who had undergone a health checkup in the last year, and who had received information about the HPV vaccine by physicians had a significant higher knowledge about the HPV infection. The 58.2% reported that they would be willing to receive the HPV vaccine. Those younger, who reported the first vaginal sexual encounter at least at 18 y, who agreed that male should receive the vaccine, who knew that both males and females can acquire the infection, and who agreed that the vaccine is an important preventive intervention, expressed more positive attitude toward willingness to receive the vaccine. More information about the HPV vaccine were required by those who agreed that the vaccine is an important preventive intervention, who reported the first vaginal sexual encounter at least at 18 y, who have had only one partner in the last year compared to students who had no partner, and who had received information about the vaccine by physicians. This study highlights a need for improved education of young males of the HPV infection and the associated diseases and about the benefit of the vaccination.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection and vaccination: Knowledge and attitudes among young males in Italy

Napolitano

Liguori

et al. 2016

Human Vaccines & Immunotherapeutics

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“…Hussain et al represents that overall HPV vaccine awareness is very low both in female and male as well as dwellers of rural and urban origin. 19 But in contrast, few studies reported that high vaccine acceptance among parents and adolescents in the general population. [20][21][22][23][24] A study by Massey et al indicated low awareness of HPV; among those who had heard of HPV, just 28% were willing to receive the HPV vaccine.…”

Section: Discussionmentioning

confidence: 99%

Assessment of knowledge and attitude of medical and nursing students towards screening for cervical carcinoma and HPV vaccination in a tertiary care teaching hospital

Gautam

Barwal

Walia

et al. 2017

Int J Community Med Public Health

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Background: Cervical cancer is the second most common cancer among women and infection with high risk human papilloma virus (HPV) is a pre-requisite for cervical cancer. The present study was undertaken to assess the knowledge regarding cervical cancer screening and HPV vaccination among medical and nursing staff.Methods: Four hundred participants; 200 MBBS students, 120 BSc nursing students and 80 staff nurses answered a standardized questionnaire which was analysed.Results: Majority of the MBBS students correctly believed that cervical cancer was not the most common cancer in females and 77.5% believed that HPV is identified in more than 50% cases. Around 80% of the respondents knew that HPV is transmitted sexually and could be transmitted during pregnancy and can affect both males and females. More than 80% of the staff nurses answered correctly that HPV could be transmitted by needle sharing and 76% believed that the infection could be symptomless. More than 80% of the participants were aware that a vaccine is available against HPV but only 5.5% were vaccinated. Though the knowledge was there but several gaps were noticed regarding HPV vaccination, the major concerns being safety, efficacy and availability of the vaccine.Conclusions: HPV is a vaccine preventable cancer and for accepting the vaccination the health professionals can play a pivotal role in raising awareness and controlling the disease.

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“…The rate of cervical cancer in women is rising each year, and it has become a large threat to women's health and a substantial burden on the global economy (Hussain et al, 2014;Skaaby et al, 2014). Its morbidity and mortality have remained at high levels in China (Du et al, 2014;Xu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Correlation of E6 and E7 levels in high-risk HPV16 type cervical lesions with CCL20 and Langerhans cells

Jiang¹,

Xue²

2015

Genet. Mol. Res.

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ABSTRACT. The human papillomavirus (HPV)16 E6 and E7 correlation with chemokine ligand (CCL)20 expression and Langerhans cells (LCs) in cervical lesions was investigated. We enrolled 43 patients with surgically treated cervical lesions from the Department of Gynecology in our hospital, and 20 controls without cervical lesions. Subjects were divided by pathology: HPV16(-) and HPV16(+) normal cervical groups (N = 10 each), and HPV16(+) cervical intraepithelial neoplasia (CIN), cervical invasive carcinoma (N = 15 each), and in situ carcinoma (N = 13) groups. E6, E7, the LC surface marker CD1a, and CCL20 were analyzed by immunohistochemistry. E6 and E7 in HPV16-type lesions were correlated with CCL20 and LCs. The average high power field cell numbers of CD1a + LCs in the HPV(-) and HPV(+) normal cervix groups, and the CINI-II, CINIII in situ and cervical carcinoma groups were 22.89 ± 4.84, 13.7 ± 2.26, 9.2 ± 1.68, 5.9 ± 1.59, and 5.5 ± 1.58, respectively. Significant between-group differences existed except between cervical carcinoma and CINIII groups (P < 0.05). CCL20 + rates in each group were 70, 60, 60, 15.38, and 13.33%, respectively. E6/E7-positive expression rates in each group were 20/20, 66.7/66.7, 76.9/69.2, and 86.67/73.3%, respectively. CCL20 was positively correlated with CD1a (r = 0.649), and negatively correlated with E7 (r = -0.946) and E6 (r = -0.949). CD1a was negatively correlated with E6 (r = -0.632) and E7 (r = -0.632). Downregulation of CCL20 leading to LC decline is a key factor in cervical lesions. High-risk HPV-type lesions might inhibit the chemokine CCL20 through E6 and E7 to escape the immune response.

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Perception of Human Papillomavirus Infection, Cervical Cancer and HPV Vaccination in North Indian Population

Cited by 59 publications

References 62 publications

Human papillomavirus infection and vaccination: Knowledge and attitudes among young males in Italy

Human papillomavirus infection and vaccination: Knowledge and attitudes among young males in Italy

Assessment of knowledge and attitude of medical and nursing students towards screening for cervical carcinoma and HPV vaccination in a tertiary care teaching hospital

Correlation of E6 and E7 levels in high-risk HPV16 type cervical lesions with CCL20 and Langerhans cells

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