The integration of the social structure and technical structure of office organizations is one of the key issues of today's business life. It is also important that the employee works in the office in a healthy, efficient, willing, and appropriate manner. Ergonomics is defined as the process of adapting people and their environment to each other physically and psychologically, as the most comfortable way to use human skills without forcing them physically and spiritually. In today's modern world, most office workers face a variety of problems in terms of the environmental and physical conditions of their work environment. This adversely affects the health and mental health of employees and their work productivity. It is necessary to organize office spaces where the employee is prevented from being inadequate in the face of developing technology, machinery and operating systems and is ergonomically considered healthy. All these arrangements must be made with the human anthropometric measurements, anatomical structure, physiological capacity, and tolerances in mind. The purpose of this study is to examine the impact of office ergonomics on business efficiency by addressing the importance of ergonomics science. In this objective, the health and work efficiency of the employees in the perspective of the components that make up the workplace have been analyzed. The study found that factors such as illumination system, sound and noise control, air conditioning system, vehicle-equipment compatibility and color preference have significant impact on employees in the working environment