Perception of Parents of Thalassemic Child to Thalassemia in Pakistan

Saleem, Noman; Anwar, Adeel; Shahid, Noor; Saleem, Rabia; Saleem, Zara; Asghar, Hannan; Zubair, Musab; Ellahi, Humna; Iqbal, Sheel

doi:10.7759/cureus.17615

Cited by 5 publications

(5 citation statements)

References 12 publications

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“…Following the weathering test on the UV absorber-coated samples, the tensile strength remained at 20 MPa, and the modulus was recorded at 1156 MPa. These results demonstrate the effectiveness of the UV absorber in enhancing the performance of the films under weathering conditions, with minimal impact on their strength and hydrophobicity, and are in line with environmental management practices [30].…”

Section: Tensile Strength and Modulussupporting

confidence: 76%

Prolonged Lifespan of Superhydrophobic Thin Films and Coatings Using Recycled Polyethylene

Saleem,

Moghal,

McKay

2024

Polymers

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High-density polyethylene (HDPE) waste poses a significant environmental challenge due to its non-biodegradable nature and the vast quantities generated annually. However, conventional recycling methods are energy-intensive and often yield low-quality products. Herein, HDPE waste is upcycled into anti-aging, superhydrophobic thin films suitable for outdoor applications. A two-layer spin-casting method combined with heating-induced crosslinking is utilized to produce an exceptionally rough superhydrophobic surface, featuring a root mean square (RMS) roughness of 50 nm, an average crest height of 222 nm, an average trough depth of −264 nm, and a contact angle (CA) of 148°. To assess durability, weathering tests were conducted, revealing the films’ susceptibility to degradation under harsh conditions. The films’ resistance to environmental factors is improved by incorporating a UV absorber, maintaining their hydrophobic properties and mechanical strength. Our research demonstrates a sustainable method for upcycling waste into high-performance, weather-resistant, superhydrophobic films.

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Section: Tensile Strength and Modulussupporting

confidence: 76%

Prolonged Lifespan of Superhydrophobic Thin Films and Coatings Using Recycled Polyethylene

Saleem,

Moghal,

McKay

2024

Polymers

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“…Hira Saleem et al [7] . recently demonstrated that a chemical compound, nitro benzaldehyde when injected directly into the tumour and subjected to beam of ultraviolet (UV) light, can eliminate cancer cells from the body within two hours.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Novel Anticancer Drugs Derived from 4‐nitrobenzaldehyde, and Investigation of Responsive Drug Delivery Systems Based on Carbon Quantum Dots.

Daniel,

Binu,

Sunish

et al. 2024

ChemistrySelect

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The present work describes the synthesis two novel derivatives of 4‐nitrobenzaldehyde through a single pot microwave assisted green synthetic method and the characterization of the synthesized drugs using UV, IR,1HNMR, Mass spectra and CHN analysis. The structure optimization of the synthesized anticancer agents was carried out using Gaussian 9. Also carbon quantum dots (CQDs) derived from amino acid precursors were synthesized (Cystine and threonine) by microwave assisted method, followed by the integration of CQDS together with 4‐nitrobenzaldehyde and its novel derivatives. The drugs were subjected to targeted drug delivery applications in cancer cell lines (PC3) The MTT assay results revealed that the CQDs conjugated with 4‐nitrobenzaldehye (D1) and one of the derivatives (D3) exhibited greater cytotoxic effects on PC3 cells compared to L929 cells. The outcomes demonstrated that this novel derivative could kill cancer cells as effectively as 4‐nitrobenzaldehyde conjugated with CQDs. Also, the potential cytotoxicity of drugs D1 and D3 were further confirmed by the apoptosis assay using flow cytometry, which also explains that apoptosis is the mechanism underlying cell death in PC3 cancer cells. The autofluorescence test were also carried out in PC3 cells lines and the drugs D1 and D3 showed significant autofluorescence in PE−A (29.9 % and 34.7 %), in Alexa Fluor‐488 (32.6 % and61.1 %) and in Bv510‐A (16.6 % and 23.2 %) respectively. Thus, the synergistic effect of CQDs together with 4‐nitrobenzaldehyde and its derivative drug D3 are indeed a promising medication towards the localized drug delivery applications in prostate cancer cells as well as the autofluorescence results will explore novel arenas in bioimaging applications.

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“…It is characterised by reduced (ᵦ+) or no (βᴼ) synthesis of the beta-globin chain of haemoglobin because of mutation on the short arm of chromosomal 11. 6,7 More than 200 distinctive thalassemia-causing mutations have been distinguished in the beta globin gene. 8 Point mutations are most frequent.…”

Section: Introductionmentioning

confidence: 99%

Beta Thalassemia Mutation Analysis in Fetal Samples for Optimal Mutation Screening Strategy

Anwer,

Manzar Bozdar,

Syeda Samia Shafaat

et al. 2023

PAFMJ

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Objective: To determine the frequency of various beta-thalassemia mutations in the prenatal period and ascertain the spectrum of mutations to optimise mutation analysis with cost reduction in testing. Study Design: Cross-sectional study Place and Duration of Study: Department of Molecular Hematology, Armed Forces Institute of Pathology (AFIP)/National University of Medical Sciences (NUMS), Rawalpindi Pakistan from Jul 2021 to Jan 2022. Methodology: Chorionic villus sampling (CVS) was performed at 12-16 weeks of gestation in target couples where both parents were known β-thalassemia carriers. Deoxyribonucleic acid (DNA) was extracted from fetal tissues, and polymerase chain reaction (PCR) was performed, and mutations were analysed with controls on polyacrylamide gel electrophoresis (PAGE). Results: Out of a total of 87 CVS samples, 17(19.5%) showed no mutation, 25(28.7%) had Beta-thalassemia major, and 45 (51.7%) were beta-thalassemia trait (heterozygous). Eight mutations were detected in the study population, and the three most common mutations were Fr 8/9, IVS 1/5 and Cd 15. Comparatively less common mutations included Cd 5, Fr 41/42, Fr 16, IVS 1/1 and Cap+1. Ethnical distribution of these mutations showed high frequency in Pathans and Punjabis compared to Sindhis, Balochis, Saraikis and Kashmiris. Conclusion: The commonly detected prevalent thalassemia mutations must be tested to provide cost-effective facilities in our resource-constrained country. This study will help in future testing strategies and optimisation of mutation analysis in our country.

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Perception of Parents of Thalassemic Child to Thalassemia in Pakistan

Cited by 5 publications

References 12 publications

Prolonged Lifespan of Superhydrophobic Thin Films and Coatings Using Recycled Polyethylene

Prolonged Lifespan of Superhydrophobic Thin Films and Coatings Using Recycled Polyethylene

Synthesis of Novel Anticancer Drugs Derived from 4‐nitrobenzaldehyde, and Investigation of Responsive Drug Delivery Systems Based on Carbon Quantum Dots.

Beta Thalassemia Mutation Analysis in Fetal Samples for Optimal Mutation Screening Strategy

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