Around 4 million children undergo inpatient surgery in the U.S. each year, however little is known about the impact of surgery and postoperative pain on children’s health-related quality of life (HRQOL) during the weeks and months after surgery. We measured pain and HRQOL in a large, heterogeneous pediatric postsurgical population from baseline to 1-month follow-up. Over a 20-month period, parents of 915 children age 2–18 years (Mean=9.6 years), 50% male, 56% white, admitted to surgical services at a children’s hospital enrolled in the study. Parent participants reported on sociodemographics, child HRQOL and pain characteristics at baseline and 1 month post-discharge. While the majority of children recovered to baseline by 1-month post-hospital discharge, 23% of children had a significant declination in HRQOL. Multivariate logistic regression analyses found that increasing child age (OR=2.1 for age 13–18), and presence of moderate-severe postsurgical pain at 1-month (OR=5.7) were significantly associated with deterioration in HRQOL from baseline to 1-month follow-up (p’s<0.05). While HRQOL returns to baseline for most children, a sizeable proportion have significant deterioration in HRQOL, which is associated with continued postsurgical pain at 1-month after hospital discharge from surgery.