Perception of teratogenic risk by pregnant women exposed to drugs and chemicals during the first trimester

Koren, Gideon; Bologa, Monica; Long, David S.; Feldman, Y; Shear, Neil H.

doi:10.1016/0002-9378(89)90186-5

Cited by 139 publications

(59 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results differed from those of previous studies that found overestimation of risk, even for non-teratogenic drugs 9,10,11,12,13,19 . This difference may be partly due to the fact that most of the previous studies included women that used specialized services (including those providing teratogen counseling), while our study sample included women attending primary care clinics.…”

Section: Discussioncontrasting

confidence: 57%

“…Few studies have assessed the perceptions of pregnant and childbearing-age women towards teratogenic risk associated with the use of medicines, and these few studies have been performed in developed countries like Canada, Spain, and Norway 9,13 . The results suggest that the perception of teratogenic risk is overestimated by pregnant women and the attending health professionals 9,10,11,12,14 . Our search in the indexed literature failed to find any studies on this issue performed in developing countries.…”

Section: Introductionmentioning

confidence: 88%

“…Most studies on risk perception associated with medicines were performed at teratogen information services or prenatal care services located in hospitals 9,11,12,14 . Women who presented spontaneously to teratogen information services may show heightened concern regarding gestational risk and possibly greater risk perception.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Perceptions by pregnant and childbearing-age women in southern Brazil towards teratogenic risk from medicines and radiotherapy

2014

View full text Add to dashboard Cite

Mistaken perception of teratogenic risk can keep pregnant women from using safe medicines. The current study analyzed women’s concepts and perceptions towards teratogenic risk from medicines and exposure to radiotherapy during pregnancy. The quantitative data resulted from interviews with 287 pregnant and non-pregnant women. Two qualitative focus groups were conducted. No significant differences were observed between the two groups in terms of perceptions of teratogenic risk. Median perceptions of non-teratogenic exposures (paracetamol and metoclopramide) were close to the expected values, while higher values were found for teratogenic exposures (misoprostol and radiotherapy). The logic women used to estimate risk was classification of medicines as “strong” or “weak”. Medicines perceived as “weak” by the women do not pose any teratogenic risk, as shown by the median perceptions close to the true values. Meanwhile, “strong” medicines were viewed as dangerous, thus explaining the high median perceptions of teratogenic exposures.

show abstract

Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

Perceptions by pregnant and childbearing-age women in southern Brazil towards teratogenic risk from medicines and radiotherapy

2014

View full text Add to dashboard Cite

show abstract

“…Even sadder, they may advise women who have been exposed to these drugs inadvertently to terminate otherwise wanted pregnancies. We have shown that women exposed to nonteratogenic drugs believe they have a 25% risk of major malformations, often leading them to seek termination of otherwise wanted pregnancies 9,10 .…”

Section: Rheumatologymentioning

confidence: 99%

Do Tumor Necrosis Factor Inhibitors Cause Malformations in Humans?

Koren¹,

Inoue²

2009

J Rheumatol

Self Cite

View full text Add to dashboard Cite

“…[1][2][3][4] This may result in discontinuation of treatment for even life-threatening medical conditions 1 or termination of an otherwise wanted pregnancy when exposure occurs. [2][3][4][5] Sudden discontinuation of medications during pregnancy may lead both to withdrawal symptoms, as well as to re-emergence of the primary disorder. 6 In previous work, 2 we have assessed the perception of teratogenic risk by 80 women attending an antenatal consultation service for different exposures in pregnancy.…”

mentioning

confidence: 99%

Perception of Teratogenic Risk and the Rated Likelihood of Pregnancy Termination: Association with Maternal Depression

et al. 2011

Self Cite

View full text Add to dashboard Cite

Objective: Women are often exposed to various medications and medical conditions during pregnancy. Unrealistically high maternal teratogenic risk perception, related to these exposures, may lead to abrupt discontinuation of therapy and (or) termination of a wanted pregnancy. The association between maternal depression and the teratogenic risk perception has not been studied, nor were the actions resulting from this perception. Our objectives were to explore the association between maternal depression, teratogenic risk perception, and the rated likelihood to terminate pregnancy. Additionally, we evaluated possible benefits of counselling. Methods:We administered the Edinburgh Postnatal Depression Scale (EPDS) to all women who attended the Motherisk Clinic between October 2007 and April 2010. A visual analogue scale was used to determine maternal risk perception in relation to the specific exposure, and the rated likelihood to terminate the pregnancy, before and after counselling. Results:We analyzed data from 413 women. Maternal teratogenic risk perception and the rated likelihood to terminate the pregnancy were significantly lower following counselling. An EPDS score of 13 or more was significantly associated with a higher rated likelihood to terminate the pregnancy (P = 0.03). In a multivariable regression analysis, an EPDS score of 13 or more was found to be an independent predictor of a higher personal teratogenic risk perception (P = 0.03). Conclusions:Both maternal depression and exposure-directed counselling are associated with maternal risk perception and the rated likelihood to terminate pregnancy. Appropriate counselling may reduce fear of teratogenicity and the likelihood of pregnancy termination.Can J Psychiatry. 2011;56(12):761-767. Clinical Implications• Counselling women about different exposures in pregnancy may reduce a maternal fear of potential teratogenicity.• Maternal depression is associated with a mother's perception of exposure-related teratogenic risk and the rated likelihood to terminate the pregnancy.• Addressing maternal depression in this setting may result in improved perinatal outcome. Limitations• The study population has specific characteristics and generalizability of the conclusions should be confirmed.• The finding that counselling results in a reduction in risk perception may reflect a maternal need to please the counsellor rather than a mother's true perception.• Maternal-rated likelihood to terminate the pregnancy does not necessarily reflect a mother's actual future action.

show abstract

Perception of teratogenic risk by pregnant women exposed to drugs and chemicals during the first trimester

Cited by 139 publications

References 1 publication

Perceptions by pregnant and childbearing-age women in southern Brazil towards teratogenic risk from medicines and radiotherapy

Perceptions by pregnant and childbearing-age women in southern Brazil towards teratogenic risk from medicines and radiotherapy

Do Tumor Necrosis Factor Inhibitors Cause Malformations in Humans?

Perception of Teratogenic Risk and the Rated Likelihood of Pregnancy Termination: Association with Maternal Depression

Contact Info

Product

Resources

About