Dysfunctional uterine bleeding (DUB) is an abnormal uterine bleeding (AUB) in the absence of organic cause. It is usually a painless, excessive, and irregular endometrial bleeding that may be prolonged, and it is not attributable to any underlying structural or systemic disease. The etiology of DUB arises out of continuing maturation of the hypothalamus, such that the eventual establishment of normal pulsatile gonadotropin release leads to normal menstrual cycle control. The European Society of Human Reproduction and Embryology (ESHRE) defined DUB as excessive bleeding (excessively heavy, prolonged, or frequent) of uterine origin, which is not due to a pelvic disease, complications of pregnancy, or systemic disease. According to ESHRE, DUB can be either ovulatory or anovulatory [1,2].Figure 2.1 shows the incidence of DUB in relation to the age of the patients and the seasonal distribution.DUB is usually seen during adolescence. In about 95 % of cases DUB is due to the late maturation of the hypothalamic-pituitary-ovarian axis. Anovulation is considered the most common cause. However, other causes as pregnancy complications, coagulation disorders, systemic diseases, and anatomical lesions of the uterus should be excluded. The pathophysiology of the disease is related to the lack of maturation of the positive feedback, which results in anovulation, excess estrogen secretion, abnormal endometrial hyperplasia, and profuse bleeding, leading to endometrium apoptosis. Endometrium sampling shows proliferation, hyperplasia, and lack of progestagenic effect [3][4][5].As endometrium is a known source of prostaglandin (PG) and especially of PGF 2a and PGE 2 production, the alteration of PGF 2a (vasoconstrictor) and PGE 2 (vasodilator) ratio have been also considered as a cause of the disease. DUB patients presented with anovulation exhibit a decreased availability of arachidonic acid, the precursor of PG synthesis. The PGF2a/ PGE 2 ratio is found decreased,