The Industrial Revolution 4.0 and the ongoing development of technology result in a digital transformation which forces higher education institutions (HEIs) to introduce significant changes. These changes necessitate a new approach that encompasses not only learning methodologies but also the university’s culture, strategy, and systemic activities. In this article we present a new, unique model of Digital Pedagogies and Digital Quality Management exemplified by the case applied approach. The model shows the intersection of the‘Digital learning foundation’,‘ Enabling factors’(digital flexibility and digital learning tools),‘Systematic quality of learning management’ and ‘Challenges of Digital Flexibility’ in HEIs. The proposed model applies practices and recommendations for Universities of Applied Sciences, making it worth disseminating in this context. The model can be useful and beneficial for facilitating peer-to-peer networking in practically oriented HEIs. The results section discusses the empirical results, supported by direct quotes from interviewees and structured codifications and proposition of model dynamics. The final section of the article describes key conclusions and limitations of the model. This study provides valuable insights for university authorities, educators, and policymakers on how digital transformation influences digital pedagogies, quality management, and finally the transition of HEIs.