Background. Entrepreneurship enables a nurse to create value by recognizing and acting on opportunities, making decisions with limited information, and remaining adaptable and resilient in conditions that are frequently uncertain and complex. Aim of the study: To assess the relation between nursing students' tendencies for entrepreneurship and career adaptability. Subjects and Method: Design: A descriptive correlation design was applied. Setting: Faculty of Nursing, Tanta University. Subjects: the proportion of the number of nursing students (n=1028) was included in this study. Tools: Two tools for data collection were used, the first University Students' Entrepreneurship Tendency Scale and the second, The Career Adaptabilities Scale. Results: Around half (49.70%) of nursing students had a high level of entrepreneurship tendencies. High percent (78.60%) of nursing students had high level of career adaptability. Conclusion: a positive statistically significant correlation was found between nursing students' overall entrepreneurship tendencies and their overall career adaptability. Recommendations: Establish entrepreneurial courses that are interdisciplinary at the university and conduct events, workshops, and methodologies for the nursing students to acquire leadership skills to be an entrepreneur.