Maintenance and sustainability of agricultural products sources are considered as the significant principles of sustainable agriculture while healthy products and continuity in production are dependent on the development of sustainable agriculture. The main purpose of this study is to evaluate the sustainability rate of cropping systems which are commonly used in Jahrom region, Iran. The study is descriptive and analytic; making use of Cochran formula, the sample size was estimated as 100 individuals who were studied based on a questionnaire in multiple cropping system or poly-cropping and single cropping systems or monoculture (wheat). The results indicate that 58% of cropping systems tend to unsustainability in Jahrom region; just 12 % of systems are categorized as sustainable while 30% of these cropping systems are relatively sustainable. Comparisons done on mean of sustainability indices in cropping systems show that the mean of sustainability in indices such as the type of cropping land, sustainable agriculture knowledge, function in a year and the attitude toward sustainable agriculture in multiple cropping systems are more significant than these indices in single cropping systems. In addition, Index of social participation (mean value) and ecological features in single cropping systems are more than these factors in multiple cropping systems. The estimated results of regression model indicate that the effective factors on sustainability of studied cropping systems include variables of land ownership, the entire cropping land, social participation, sustainable agricultural knowledge, and the obstacles in achieving sustainability in agriculture which covers and describes 70% of changes in dependent variables.