Purpose/objectivesThe aim of this study is to evaluate students’ perceptions of the reinforcement of knowledge via innovative, case‐based, hands‐on learning regarding indirect prosthetic material choice.MethodsSix different clinical cases that represented common prosthetics were used in this simulation training. In each case, clinical pictures were associated with three‐dimensional (3D)‐printed replicates of final restorations and PolyJet polychromatic models with the goal of enabling students to deliberate and exchange ideas in small groups. After a debriefing session regarding the therapeutic potentialities of the first three cases alongside teachers, a lecture concerning prosthetic material choices was provided, and a zirconia crown was stained by each student to enable them to obtain a better understanding of the dental technician profession. Finally, the latter three cases were studied and analyzed in the same manner. The students’ perceived reinforcement of knowledge was recorded before and 1 month after the hands‐on simulation training experience, and their satisfaction was evaluated immediately thereafter on Likert scales. Students’ perceived reinforcement of knowledge was subjected to statistical evaluation.ResultsA high level of overall satisfaction was observed (4.60). All of the items pertaining to students’ satisfaction received scores >3. One month after this hands‐on approach, students’ confidence in their ability to choose a material on the basis of its mechanical, optical, and luting properties increased significantly (from 2.58 to 3.64; from 2.83 to 3.64; and from 2.72 to 3.58, respectively) (p < 0.05).ConclusionsThis innovative, hands‐on approach had a significant positive effect on students’ perceived reinforcement of knowledge.