Substances derived from herbals are much in demand in doping practices because of their interesting biological properties for physical exercise and sport. This review aimed to investigate anti-fatigue herbals, their properties, analysis methods and toxicity. Data indicate that phytomolecules have beneficial effects on the physiological and biochemical parameters of the body undergoing exercise. They reduce fatigue and promote recovery by improving antioxidant enzyme activities, immune responses, blood pressure, body composition and by reducing the accumulation of toxic metabolites and systemic inflammation. Thus, the use of herbal could provide relief to people who exert intense physical activities such as farmers and athletes; for this, these peoples must do careful, the use of doping herbal must be done in accordance with all the previsions which take into account the need for the use of herbal supplement, the doses. In addition, these benefits attributed to herbals should not conceal the drawbacks of using them in sport.Some phytomolecules are toxic when used in large quantities, and others, in this case alkaloids, should be avoided by athletes.