Artificial intelligence (AI) will continue to increase its significant impact on the everyday acquisition, interpretation, and application of data in our healthcare system. It is difficult to predict whether and to what extent AI will change the health status of patients, but it certainly will change the way decisions are made, how healthcare is delivered, and the ways providers, patients, and healthcare enterprises interact with and use data from an increasing array of sources. Radiology has often been at the forefront of technological change in healthcare and the AI revolution is no different. The lessons radiology has learned to date, its successes and challenges, can help provide guidance for other specialties, especially since radiology interacts with and cross-cuts nearly every other specialty and touches nearly every patient at least once in his or her lifetime.