Images synthesized using depth-imagebasedrendering (DIBR) techniques may suffer from complex structural distortions. The goal of the primary visual cortex and other parts of brain is to reduce redundancies of input visual signal in order to discover the intrinsic image structure, and thus create sparse image representation. Human visual system (HVS) treats images on several scales and several levels of resolution when perceiving the visual scene. With an attempt to emulate the properties of HVS, we have designed the no-reference model for the quality assessment of DIBR-synthesized views. To extract a higher-order structure of high curvature which corresponds to distortion of shapes to which the HVS is highly sensitive, we define a morphological oriented Difference of Closings (DoC) operator and use it at multiple scales and resolutions. DoC operator nonlinearly removes redundancies and extracts fine grained details, texture of an image local structure and contrast to which HVS is highly sensitive. We introduce a new feature based on sparsity of DoC band. To extract perceptually important loworder structural information (edges), we use the non-oriented Difference of Gaussians (DoG) operator at different scales and resolutions. Measure of sparsity is calculated for DoG bands to get scalar features. To model the relationship between the extracted features and subjective scores, the general regression neural network (GRNN) is used. Quality predictions by the proposed DoC-DoG-GRNN model show higher compatibility with perceptual quality scores in comparison to the tested state-of-theart metrics when evaluated on four benchmark datasets with synthesized views, IRCCyN/IVC image/video dataset, MCL-3D stereoscopic image dataset and IST image dataset.