Perchlorate Exposure and Thyroid Function in Ammonium Perchlorate Workers in Yicheng, China

Chen, Hongxia; Wu, Libing; Wang, Xia; Liu, Qin; Ding, Miaohong; Peng, Kai-liang; Meng, Zhe

doi:10.3390/ijerph110504926

Cited by 12 publications

(4 citation statements)

References 26 publications

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“… Although these correlations are clearly demonstrated in experimental studies, the relationship between human perchlorate exposure and thyroid function disfunction are extremely controversial . Actually, even though some reports have shown an inverse correlation between urinary perchlorate concentration and thyroid hormone levels, other studies have not consistently supported this correlation . Even so, there is a general agreement that perchlorate exposure seems to be more harmful to susceptible individuals, as pregnant women, children and individuals living in iodine deficient areas …”

Section: Discussionmentioning

confidence: 97%

Evaluation of hypothalamus‐pituitary‐thyroid axis function by chronic perchlorate exposure in male rats

Serrano‐Nascimento

Calil-Silveira

Dalbosco

et al. 2017

Environmental Toxicology

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Perchlorate is a widespread endocrine disruptor that was previously correlated with increased serum TSH levels and decreased thyroid hormones production both in animals and humans. Even so, the regulation of gene/protein expression in the hypothalamus, pituitary and thyroid by chronic perchlorate exposure was not completely elucidated. Therefore, this study aimed to investigate the underlying mechanisms involved in the disruption of hypothalamus-pituitary-thyroid axis by chronic perchlorate exposure. Male Wistar rats were treated or not with NaClO in the drinking water (35 mg/Kg/day) for 60 days. Thereafter, hormone/cytokines serum levels were measured through multiplex assays; genes/proteins expression were investigated by qPCR/Western Blotting and thyroid morphology was evaluated through histological analysis. Serum TSH levels were increased and serum T /T levels were decreased in perchlorate-treated animals. This treatment also altered the thyrotropin-releasing hormone mRNA/protein content in the hypothalamus. Additionally, the expression of both subunits of TSH were increased in the pituitary of perchlorate-treated rats, which also presented significant alterations in the thyroid morphology/gene expression. Furthermore, perchlorate exposure reduced liver Dio1 mRNA expression and increased the content of pro-inflammatory cytokines in the thyroid and the serum. In conclusion, our study adds novel findings about the perchlorate-induced disruption of the hypothalamus-pituitary-thyroid axis gene/protein expression in male rats. The data presented herein also suggest that perchlorate induces thyroid and systemic inflammation through the increased production of cytokines. Taken together, our results suggest that perchlorate contamination should be monitored, especially in the individuals most susceptible to the deleterious effects of reduced levels of thyroid hormones.

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Section: Discussionmentioning

confidence: 97%

Evaluation of hypothalamus‐pituitary‐thyroid axis function by chronic perchlorate exposure in male rats

Serrano‐Nascimento

Calil-Silveira

Dalbosco

et al. 2017

Environmental Toxicology

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“…In particular, perchlorate factory workers and the population of large cities where smog phenomenon occurs are the most vulnerable groups to this type of exposure [6]. Several studies [76][77] conducted on the factory workers, who inhaled dust containing subclinical doses of perchlorate for a few hours a day showed no significant changes in the level of thyroid hormones in the blood compared to the control group, despite the increase in the content of perchlorate excreted in the urine. Study from China also informs about the increased amount of ClO 4…”

Section: Routes Of Exposurementioning

confidence: 99%

“…Apart from the research carried out in the general population, there are some studies concerned on occupational risk of perchlorate exposure in heavy industry employees. Chen et al [129] investigated differences in perchlorate concentration in employees of the fireworks factory in China, who were exposed to perchlorate to varying degrees. The content of ClO 4 − in the urine of employees finishing their shift was median (range) 8.89 (0.92-24.71) μg/L for exposed group (51 people) and 5.56 (0.37-20.55) μg/L control group (41 people).…”

Section: Occupational Risk Assessment In Factory Workersmentioning

confidence: 99%

Perchlorate – properties, toxicity and human health effects: an updated review

Niziński

Błażewicz

Kończyk

et al. 2020

Reviews on Environmental Health

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Interest in perchlorate as environmental pollutant has increased since 1997, when high concentrations have been found in the waters of the Colorado River, USA. Perchlorate is very persistent in nature and it is slowly degraded. Although harmful effects of large doses of perchlorate on thyroid function have been proven, the environmental effects are still unclear. The primary objective of the present review is to collect prevailing data of perchlorate exposure and to discuss its impact on human health. The results show that more than 50% of reviewed works found significant associations of perchlorate exposure and human health. This review consists of the following sections: general information of perchlorate sources, its properties and determination methods, role and sources in human body including food and water intake, overview of the scientific literature on the research on the effect of perchlorate on human health from 2010 to 2020. Finally, conclusions and recommendations on future perchlorate studies concerning human exposure are presented.

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“…[4] An observational study carried out at an ammonium perchlorate production factory in China found no effect on thyroid function from long-term exposure to ammonium perchlorate. [13].…”

Section: Discussionmentioning

confidence: 99%

Possible Effects of Perchlorate Contamination of Drinking Water on Thyroid Health

Orathel

Thomas

Chandramohanakumar

et al. 2020

Journal of Thyroid Research

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Background. Perchlorate is an anion that occurs as a contaminant in groundwater. It originates from the improper disposal of ammonium perchlorate, a component of rocket fuel. The objective of this study was to explore whether the exposure to perchlorate in drinking water had an impact on the thyroid function of the population residing near an ammonium perchlorate plant in Kerala. Methodology. Using an ecological study design, we compared the serum levels of thyroid-stimulating hormone, thyroxine, and thyroid peroxidase antibodies among a representative sample of 289 study subjects from the area surrounding the ammonium perchlorate enrichment plant to 281 study subjects in a control area. Results. The perchlorate concentration in the groundwater varied from 1600 ppb to 57,000 ppb in the 10 samples from the contaminated area and was below 24 ppb in all locations in the control area. No significant differences were found in the mean serum TSH concentration and mean T4 levels between the subjects from the contaminated area and the control area. On regression analysis, perchlorate contamination was not found to be a significant predictor of TSH. Conclusion. This study did not find any significant association between perchlorate in drinking water and changes in thyroid hormone levels. Our findings indicate the need for further investigation of this hypothesis using urinary perchlorate as a measure of individual exposure.

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Perchlorate Exposure and Thyroid Function in Ammonium Perchlorate Workers in Yicheng, China

Cited by 12 publications

References 26 publications

Evaluation of hypothalamus‐pituitary‐thyroid axis function by chronic perchlorate exposure in male rats

Evaluation of hypothalamus‐pituitary‐thyroid axis function by chronic perchlorate exposure in male rats

Perchlorate – properties, toxicity and human health effects: an updated review

Possible Effects of Perchlorate Contamination of Drinking Water on Thyroid Health

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