“…Despite the lack of long-term recurrence and survival data, radiofrequency ablation (RFA) or cryotherapy performed either percutaneously under image guidance or laparoscopically, is a viable management option in patients with tumours less than 3 cm in diameter, with infrequent complications; they do, however, have a slightly higher risk of local recurrence compared to PN. [72][73][74] Currently, patients considered for ablative approaches are those with severe medical comorbidities precluding surgical extirpation, or in patients with multiple bilateral lesions, possibly due to underlying genetic predispositions (Birt-Hogg-Dubé syndrome, Von Hippel-Lindau disease). Several technologies and approaches are differentially used with success, although long-term oncologic outcomes are not yet available.…”