We present 11 cases of percutaneous transcatheter occlusion of atrial septal defects (ASDs) in adults, including multi-fenestrated ASD, balloon-assisted deployment of ASD occlude, dilator-assisted deployment of ASD occlude, "cobra"-shaped disfiguration of the left disc, ASD with deficient aortic rim, pulmonary vein-assisted deployment of ASD occlude, "high" ASD, large Chiari network, double interatrial septum, snaring a runaway occluder, and right ventricular diastolic dysfunction causing cyanosis. Each case is followed by a practical discussion of the special dilemmas, complications, and challenges that may occur during common procedures.