Percutaneous Core Needle Biopsy vs. Fine Needle Aspiration in Diagnosing Benign Lung Lesions

Greif, Joel; Marmor, Sylvia; Schwarz, Yehuda; Staroselsky, Alexander N.

doi:10.1159/000331287

Cited by 73 publications

(41 citation statements)

References 17 publications

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“…Only 2 among 59 benign specific cases, 1 among 50 benign nonspecific cases, and 1 among 12 nondiagnostic cases had aspiration cytology only. Despite the use of a core biopsy, the diagnostic yield for specific benign disease was lower than in previous reports (4,15). Although there were no false negative cases, the sensitivity for benign specific disease was only 55.7%.…”

Section: Discussioncontrasting

confidence: 60%

“…Prior studies reported a remarkably high success rate for a specific diagnosis of benign disease after a transthoracic core biopsy (4,15,21,22). We also performed core biopsy for diagnosis of benign disease in a majority of patients.…”

Section: Discussionmentioning

confidence: 93%

“…The pulmonary lesion was diagnosed as a malignancy if the aspiration cytology or biopsy specimen showed malignant cells or was highly suggestive of a malignancy. If no malignant cells were found in the TNAB specimen, the lesions were classified into three groups according to the pathology reports: benign specific, benign non-specific or non-diagnostic (15,18). The benign specific diagnosis was used for TNAB results that led to a specific benign diagnosis such as hamartoma or tuberculosis.…”

Section: ) Classification Of Lung Lesionsmentioning

confidence: 99%

“…Some studies have found that CT-guided TNAB for small lung lesions can produce a diagnostic yield comparable with larger lesions (13,14). In addition, the diagnosis of specific benign diseases can also be made with a high success rate (4,15). However, inconclusive results such as nonspecific or nondiagnostic benign results after TNAB are not uncommon and present a clinical dilemma (16,17).…”

Section: Introductionmentioning

confidence: 99%

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Inconclusive Result from CT Guided Transthoracic Needle Aspiration and Biopsy: Affecting Factors and Final Outcome

et al. 2011

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Purpose:Inconclusive results from com puted tom ography (CT)-guided transthoracic needle aspiration and biopsy (TNAB) performed for lung lesions presents a clinical dilem m a. The purpose of this study was to determ ine the factors affecting an inconclusive result from a CT guided TNAB, and to evaluate the final outcomes of these inconclusive results. Materials and Methods: The m edical records and radiologic features of 331 patients with lung lesion who received CT guided TNAB were analyzed retrospectively. The results of the TNAB were classified as conclusive (m alignancy or specific benign diagnosis) or inconclusive (nonspecific benign or nondiagnostic). Results: Of the 331 cases, 269 (81.3%) were diagnosed as a malignancy (210) or a specific benign lesion (59) after the first TNAB. The rem aining 62 (18.7% ) were inconclusive. Benign disease, a lesion size ≤15 mm, and morphology of the consolidation type were features significantly correlated with inconclusive results. Of these 62 inconclusive cases a second TNAB was perform ed in 23, and conclusive diagnoses were obtained in 19 (82.6%). Surgery or radiographic follow up was done in other cases. Finally, among the 62 inconclusive results on the first CT guided TNAB, 16 lesions were diagnosed as malignant, 26 were classified as specific benign disease, and the remaining 20 were defined as nonspecific inflam mation. Age over 50 and morphology of a nodule or a mass type were significantly correlated with a malignancy in these 62 cases with inconclusive results on the first TNAB. Conclusion: A final diagnosis of benign disease was significantly higher after the CT guided TNAB was inconclusive for lesions ≤15 mm that had consolidation type m orphology. Despite the application of core biopsy procedures, there continue to be appreciable num bers of inconclusive results after the first CT guided TNAB. A repeat CT guided TNAB had a high diagnostic yield in these cases and therefore should be considered for cases with inconclusive results. (J Lung Cancer 2011;10(2):94 101)

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 93%

Section: ) Classification Of Lung Lesionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inconclusive Result from CT Guided Transthoracic Needle Aspiration and Biopsy: Affecting Factors and Final Outcome

et al. 2011

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“…There are conflicting data in the literature regarding the accuracy and usefulness of these techniques for the evaluation of intrathoracic lesions (Bocking et al, 1995;Arakawa et al, 1996;Greif et al, 1999;Nasuti et al, 2002;Kravtsov et al, 2014). Most previous reports present a limited number of cases and few studies have directly compared these two methods when treating the same patient (Gong et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of Fine Needle Aspiration Cytology versus Concurrent Core Needle Biopsy in Evaluation of Intrathoracic Lesions: a Retrospective Comparative Study

Eftekhar-Javadi

Kumar²,

Mirzaie³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Increase of core biopsies in visceral organs–experience at one institution

Gupta¹,

Wang²

2010

Diagnostic Cytopathology

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All targeted core biopsies in the surgical pathology file and all cytology specimens from liver, lung, kidney, and pancreas accessioned in 1997, 2002, and 2007 in the Pathology Department at the Beth Israel Deaconess Medical Center, Boston, were culled. Cytology specimen type [touch imprint smear (TIS) from core-only, fine-needle aspiration (FNA)-only, or both] was determined. Seven hundred and fifty-eight targeted core biopsies were identified from the years 1997 (162), 2002 (249), and 2007 (347). Eight hundred and seventy-eight cytology specimens from the years 1997 (127), 2002 (264), and 2007 (487) were included. The overall percentage of TIS-only of all cytology specimens increased from 5.5 to 31% in 10 years and most prominently in the liver (14% in 1997 to 87% in 2007). In spite of the increasing use of core biopsies, the volume of cytology specimens from these organs increased from 127 in 1997 to 487 in 2007.

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Percutaneous Core Needle Biopsy vs. Fine Needle Aspiration in Diagnosing Benign Lung Lesions

Cited by 73 publications

References 17 publications

Inconclusive Result from CT Guided Transthoracic Needle Aspiration and Biopsy: Affecting Factors and Final Outcome

Inconclusive Result from CT Guided Transthoracic Needle Aspiration and Biopsy: Affecting Factors and Final Outcome

Diagnostic Accuracy of Fine Needle Aspiration Cytology versus Concurrent Core Needle Biopsy in Evaluation of Intrathoracic Lesions: a Retrospective Comparative Study

Increase of core biopsies in visceral organs–experience at one institution

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