Percutaneous coronary interventional strategies for treatment of in-stent restenosis: a network meta-analysis

Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment

“…Again, RIBS IV cohort is still too small to give a conclusive result (309 patients overall), newer generation DCB should be tested in this challenging setting, furthermore, DCB presents the great advantage to avoid the onion-skin phenomenon in which new metal layer is applied to previous implanted DES. Alfonso (64). Table 4 shows a summary of the most relevant studies that investigated DCB for BMS/DES restenosis.…”

Predictors of Recurrent In-Stent Restenosis After Paclitaxel-Coated Balloon Angioplasty

“…Two meta-analyses of the effect of DCB to treat ISR showed that DCB reduces the risk of major adverse cardiac events, compared with not only conventional BA but also additional DES implantation, 8,9 and 1 meta-analysis of PCI strategies for ISR also demonstrated the better angiographic and clinical outcomes without the addition of metal stent layers. 10 Studies on the long-term clinical outcomes and safety after PCB angioplasty for both BMS-ISR and DES-ISR, compared with conventional BA, reported no stent thrombosis. 13, 14 Although PCB angioplasty was expected to be an alternative to repeat DES implantation for ISR, recurrent ISR still occurs in the clinical setting.…”

Drug-eluting stent restenosis treatment: an “old” stent, a “new” balloon or a “newer” scaffold?

“…With these premises, we would like to suggest that a meta-analysis is like a good dish: it strongly depends on quality ingredients. In fact, a recent meta-analysis by Siontis and colleagues (8) have reported an interesting network meta-analysis comparing various treatment strategy for ISR, both bare metal stent (BMS) and DES, running from brachytherapy to latest DES available (i.e., EES). This study included 27 trials published from 2001 to 2014.…”