Percutaneous Image-Guided Cryoablation of Musculoskeletal Metastases: Pain Palliation and Local Tumor Control

Wallace, Adam N.; McWilliams, Sebastian; Connolly, S.; Symanski, John S.; Vaswani, Devin; Tomasian, Anderanik; Vyhmeister, Ross; Lee, Ashley M.; Madaelil, Thomas P; Hillen, Travis J.; Jennings, Jack W.

doi:10.1016/j.jvir.2016.07.026

Cited by 44 publications

(53 citation statements)

References 31 publications

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“…Although minimally invasive percutaneous thermal ablation has been utilized to achieve pain palliation and radiographic local tumour control in the setting of visceral and osseous metastatic disease of many tumour types, [10][11][12][13][14][15][21][22][23][24][25] the various tumour histologies included in these studies precludes identification of tumour-specific response to percutaneous ablative therapy. To our knowledge, no published study has specifically addressed the use of percutaneous thermal ablation alone or in combination with cementoplasty in pain palliation and local tumour control of RCC osseous metastases.…”

Section: Discussionmentioning

confidence: 99%

“…Cryoablation was performed using the Visual-ICE Cryoablation System (Galil Medical; Arden Hills, Minnesota) for 16 tumours (27%, 16/59). The median number of cryoprobes used to treat a single tumour was 5 (range, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. When multiple cryoprobes were needed to produce a contiguous ice ball that encompassed the planned treatment volume, an inter-probe distance of 10-15 mm was implemented.…”

Section: Thermal Ablation Proceduresmentioning

confidence: 99%

“…It should be noted that intact cortex does not prevent expansion of ice ball which should be taken into consideration when cryoablating vertebral tumours. 13 Radiofrequency ablation (RFA) was performed using the STAR tumour ablation system (Merit Medical Systems Inc., South Jordan, Utah) for 43 tumours (73%, 43/59). The navigational RFA electrode is placed into the central portion of the tumour, and if needed, tip is articulated to reach tumour components not readily accessible from a straight approach.…”

Section: Thermal Ablation Proceduresmentioning

confidence: 99%

“…When the intent included local tumour control, technical success was defined as complete tumour volume coverage with the ablation zone plus a 3-5 margin to ensure adequate cell death. 13,14,18 Cementoplasty Cementoplasty (or vertebral augmentation) was performed during the same treatment session if the patient reported mechanical pain or there was a pre-existing or imminent risk of pathologic fracture using the StabiliT System (Merit Medical Systems Inc., South Jordan, Utah) through existing introducer working cannulas used for ablation. A total of 43 tumours (73%, 43/59) underwent cementoplasty or vertebral augmentation following ablation.…”

Section: Thermal Ablation Proceduresmentioning

confidence: 99%

“…8,9 Minimally invasive percutaneous thermal ablation has been recently described for management of osseous metastases in cohorts consisting of heterogeneous tumour histologies to achieve both pain palliation [10][11][12] and radiographic local tumour control. [13][14][15] The purpose of this study is to systematically and specifically evaluate the safety and efficacy of percutaneous thermal ablation alone or in combination with cementoplasty for pain palliation and local tumour control of RCC osseous metastases.…”

Section: Introductionmentioning

confidence: 99%

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Percutaneous thermal ablation alone or in combination with cementoplasty for renal cell carcinoma osseous metastases: Pain palliation and local tumour control

et al. 2020

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Introduction: To evaluate the safety and efficacy of minimally invasive percutaneous thermal ablation alone or in combination with cementoplasty for pain palliation and local tumour control of renal cell carcinoma osseous metastases. Methods: Imaging-guided thermal ablation was performed in 59 renal cell carcinoma osseous metastatic tumours in 23 patients (concomitant cementoplasty in 43 tumours) selected following multidisciplinary consultations to achieve local tumour control and pain palliation (75%, 44/59) or pain palliation alone (25%, 15/59) in this retrospective study. Tumour characteristics, procedural details and complications were documented. Pain palliation was assessed using pre-and post-procedural Numeric Rating Scale scores at 1week, 1-month, 3-month and 6-month time intervals. Pre-and post-procedural cross-sectional imaging was reviewed to assess local tumour control rates at 3-month, 6-month, and 12-month post-treatment time intervals. Results: All procedures were technically successful and performed as pre-operatively planned. The median pre-and post-procedural Numeric Rating Scale scores were 8.0 and 3.0 (at all time intervals), respectively (P < 0.001). Local tumour control rates were 100% (40/40), 100% (36/36) and 85% (28/33) at ≥3 months, ≥6 months and ≥12 months post-procedural time intervals, respectively. There was 1 minor complication (1.7%, 1/59). Conclusions: Percutaneous thermal ablation alone or in combination with cementoplasty is safe and effective for pain palliation and local tumour control of renal cell carcinoma osseous metastases.

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Section: Discussionmentioning

confidence: 99%

Section: Thermal Ablation Proceduresmentioning

confidence: 99%

Section: Thermal Ablation Proceduresmentioning

confidence: 99%

Section: Thermal Ablation Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Percutaneous thermal ablation alone or in combination with cementoplasty for renal cell carcinoma osseous metastases: Pain palliation and local tumour control

et al. 2020

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Image‐guided percutaneous cryoablation of unresectable sacrococcygeal chordoma: Feasibility and outcome in a selected group of patients with long term follow‐up

Cherix

Traverso

Bazan

et al. 2020

Journal of Surgical Oncology

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BackgroundChordoma is a rare malignant tumor of the axial skeleton. Percutaneous cryoablation (PCA) is a minimally invasive technique that allows freezing of tumors under imaging control. The purpose of our retrospective study was to investigate the outcome of PCA in a selected cohort of patients with sacrococcygeal chordoma, with a minimum of 5 years follow‐up.Materials and MethodsFour patients were treated in 10 sessions. The mean follow‐up was 57.3 months. We evaluated the feasibility, the procedure‐related complications, the impact on pain control and oncological outcomes.ResultsFreezing of 100% of the tumor volume was possible in 60%. Pain control was not reliably evaluable. Local recurrence occurred in 90% of the treated lesions; the mean time to progression was 8.1 months (range 1.5–16). At last follow‐up, one patient had died of the disease, one of another cause and one was receiving the best supportive care. The only patient alive without the disease had received additional carbon‐ion radiotherapy. The 5‐year survival rate after index PCA was 50%.ConclusionComplete freezing of the tumor was technically challenging, mainly due to the complex local anatomy. Recurrence occurred in 90% of the lesions treated. PCA should be considered with caution in the curative management of sacrococcygeal chordoma.

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A case of progressive, metastatic adamantinoma in a pediatric patient

D’Souza

Bahrami

Akeson

et al. 2021

Pediatric Blood & Cancer

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Percutaneous Image-Guided Cryoablation of Musculoskeletal Metastases: Pain Palliation and Local Tumor Control

Cited by 44 publications

References 31 publications

Percutaneous thermal ablation alone or in combination with cementoplasty for renal cell carcinoma osseous metastases: Pain palliation and local tumour control

Percutaneous thermal ablation alone or in combination with cementoplasty for renal cell carcinoma osseous metastases: Pain palliation and local tumour control

Image‐guided percutaneous cryoablation of unresectable sacrococcygeal chordoma: Feasibility and outcome in a selected group of patients with long term follow‐up

A case of progressive, metastatic adamantinoma in a pediatric patient

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