Percutaneous immunization with 40-nm antigen-encapsulated elastic liposomes

Kakami, Yuki; Takeuchi, Issei; Makino, Kimiko

doi:10.1016/j.colsurfa.2019.01.023

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…These small values of PDI (<0.3) indicate a very narrow size population of nanoliposomes in both fresh samples. These results are similar to those previously reported by Kakami et al . and Yusuf and Casey, who reported 128 and 140 nm for nanoliposomes obtained by the extrusion process, respectively.…”

Section: Results and Discussionsupporting

confidence: 93%

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Build-Up of a 3D Organogel Network within the Bilayer Shell of Nanoliposomes. A Novel Delivery System for Vitamin D₃: Preparation, Characterization, and Physicochemical Stability

Ghiasi

Eskandari

Golmakani

et al. 2021

J. Agric. Food Chem.

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The inherent thermodynamic instability of liposomes during production and storage has limited their widespread applications. Therefore, a novel structure of food-grade nanoliposomes stabilized by a 3D organogel network within the bilayer shell was developed through the extrusion process and successfully applied to encapsulate vitamin D 3 . A huge flocculation and a significant reduction of zeta potential (−17 mV) were observed in control nanoliposomes (without the organogel shell) after 2 months of storage at 4 °C, while the sample with a gelled bilayer showed excellent stability with a particle diameter of 105 nm and a high negative zeta potential (−63.4 mV), even after 3 months. The development of spherical vesicles was confirmed by TEM. Interestingly, the gelled bilayer shell led to improved stability against osmotically active divalent salt ions. Electron paramagnetic resonance confirmed the higher rigidity of the shell bilayer upon gelation. The novel liposome offered a dramatic increase in encapsulation efficiency and loading of vitamin D 3 compared to those of control.

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Section: Results and Discussionsupporting

confidence: 93%

“…These results are similar to those previously reported by Kakami et al. 49 and Yusuf and Casey, 50 who reported 128 and 140 nm for nanoliposomes obtained by the extrusion process, respectively.…”

Section: Results and Discussionsupporting

confidence: 92%

Build-Up of a 3D Organogel Network within the Bilayer Shell of Nanoliposomes. A Novel Delivery System for Vitamin D₃: Preparation, Characterization, and Physicochemical Stability

Ghiasi

Eskandari

Golmakani

et al. 2021

J. Agric. Food Chem.

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show abstract

“…Liposomes with a mean volume diameter of 40 nm significantly promote antibody production compared with albumin solution and liposomes with a mean volume diameter of 130 nm, with greater penetration and accumulation of the 40 nm elastic liposomes compared with the 130 nm. 55 Thus, nano-liposomes loaded with nutrients are expected to improve permeation and stability for delivery. Although liposomes have been widely used, they have some disadvantages, such as toxicity and lower stability at different pH.…”

Section: Liposomesmentioning

confidence: 99%

“…The deposition of nutrients into the deep skin layers can be affected by lipid composition, thermodynamic properties, particle size and surface charge in liposome formulations. Liposomes with a mean volume diameter of 40 nm significantly promote antibody production compared with albumin solution and liposomes with a mean volume diameter of 130 nm, with greater penetration and accumulation of the 40 nm elastic liposomes compared with the 130 nm 55 . Thus, nano‐liposomes loaded with nutrients are expected to improve permeation and stability for delivery.…”

Section: Carrier Systemsmentioning

confidence: 99%

Recent advances in delivery of transdermal nutrients: A review

Fan,

Huang,

2023

Experimental Dermatology

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Nutrients provide vital functions in the body for sustained health, which have been shown to be related to the incidence, prevention and treatment of disease. However, limited bioavailability, loss of targeting specificity and the increased hepatic metabolism limit the utilization of nutrients. In this review, we highlight transdermal absorption of nutrients, which represents an opportunity to allow great use of many nutrients with promising human health benefits. Moreover, we describe how the various types of permeation enhancers are increasingly exploited for transdermal nutrient delivery. Chemical penetration enhancers, carrier systems and physical techniques for transdermal nutrient delivery are described, with a focus on combinatorial approaches. Although there are many carrier systems and physical techniques currently in development, with some tools currently in advanced clinical trials, relatively few products have achieved full translation to clinical practice. Challenges and further developments of these tools are discussed here in this review. This review will be useful to researchers interested in transdermal applications of permeation enhancers for the efficient delivery of nutrients, providing a reference for supporting the need to take more account of specific nutritional needs in specific states.

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“…For example, cationic liposomes with higher charge intensities induced antigen uptake by DCs, DC maturation, and antigen-specific IgG production to a greater extent [40]. However, negatively charged NPs can sometimes also be efficiently taken up by APCs [41][42][43][44]. Negatively charged nanovaccines with a size smaller than 100 nm may have potentially more specific immunomodulatory capacity, as they do not interact with positively charged non-immune cells [45].…”

Section: Introductionmentioning

confidence: 99%

Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

Duong

Shalash

et al. 2021

Vaccines

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The production of subunit nanovaccines relies heavily on the development of a vaccine delivery system that is safe and efficient at delivering antigens to the target site. Nanoparticles have been extensively investigated for vaccine delivery over the years, as they often possess self-adjuvanting properties. The conjugation of antigens to nanoparticles by covalent bonds ensures co-delivery of these components to the same subset of immune cells in order to trigger the desired immune responses. Herein, we review covalent conjugation strategies for grafting protein or peptide antigens onto other molecules or nanoparticles to obtain subunit nanovaccines. We also discuss the advantages of chemical conjugation in developing these vaccines.

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Percutaneous immunization with 40-nm antigen-encapsulated elastic liposomes

Cited by 6 publications

References 23 publications

Build-Up of a 3D Organogel Network within the Bilayer Shell of Nanoliposomes. A Novel Delivery System for Vitamin D₃: Preparation, Characterization, and Physicochemical Stability

Build-Up of a 3D Organogel Network within the Bilayer Shell of Nanoliposomes. A Novel Delivery System for Vitamin D₃: Preparation, Characterization, and Physicochemical Stability

Recent advances in delivery of transdermal nutrients: A review

Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

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Percutaneous immunization with 40-nm antigen-encapsulated elastic liposomes

Cited by 6 publications

References 23 publications

Build-Up of a 3D Organogel Network within the Bilayer Shell of Nanoliposomes. A Novel Delivery System for Vitamin D3: Preparation, Characterization, and Physicochemical Stability

Build-Up of a 3D Organogel Network within the Bilayer Shell of Nanoliposomes. A Novel Delivery System for Vitamin D3: Preparation, Characterization, and Physicochemical Stability

Recent advances in delivery of transdermal nutrients: A review

Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

Contact Info

Product

Resources

About

Build-Up of a 3D Organogel Network within the Bilayer Shell of Nanoliposomes. A Novel Delivery System for Vitamin D₃: Preparation, Characterization, and Physicochemical Stability

Build-Up of a 3D Organogel Network within the Bilayer Shell of Nanoliposomes. A Novel Delivery System for Vitamin D₃: Preparation, Characterization, and Physicochemical Stability