Percutaneous Interventions Alter the Hemostatic Profile of Patients With Unstable Versus Stable Angina

Abstract

These data suggest that elevated plasma levels of t-PA and vWF may correlate with instability of atheromatous plaques, and that their decrease after coronary interventions may reflect plaque reendothelialization and stabilization.

Markers of hypercoagulation and von Willebrand factor in postmenopausal women with unstable coronary artery disease. Discriminatory ability regarding unstable coronary artery disease and coronary atherosclerosis using receiver operating characteristics

“…Our results indicate a hypercoagulable state in women with unstable CAD and coronary atherosclerosis compared with the control group, whereas this does not seem to be the case in patients with normal vessels. Furthermore, our results are in agreement with other investigators who have found elevated plasma levels of one or more markers of coagulation and thrombosis in patients with unstable angina, myocardial infarction or coronary atherosclerosis compared with a control group with stable angina or normal coronary vessels [2–8]. There are also studies which have found no signs of hypercoagulation in these patients [9].…”

“…Previous studies on hypercoagulability in CAD have shown diverging results. Some have found elevated plasma levels of one or more markers of coagulation and thrombosis in patients with unstable angina or myocardial infarction compared with patients with stable angina or a control group [2–5]. Others have found elevated plasma levels in patients with angiographically documented coronary atherosclerosis compared with those with no atherosclerosis [6–8].…”

Plasminogen and plasmin activity in patients with coronary artery disease

“…There have been several studies examining components of the fibrinolytic system in the plasma of CAD patients with acute, unstable angina compared to chronic, stable angina, before and after coronary intervention. In most cases, they have not found significant differences between the two groups [16–21]. However, a study that examined fibrinolysis/proteolysis in patients with stable angina, when compared with those with no known disease, showed that the fibrinolytic/proteolytic balance is impaired in those with stable angina.…”

Effects of enhanced counterpulsation on vascular cell release of coagulation factors

“…Previous research has revealed that medical intervention may alter levels of endothelial hemostatic and growth factors. [8][9][10][11][12][13][14][15][16] Yazdani et al 12 revealed higher tPA and vWF levels in patients with unstable angina versus stable angina. However, after percutaneous coronary intervention, there was no significant difference in plasma levels of tPA and vWF.…”