Percutaneous intramyocardial stem cell injection in patients with acute myocardial infarction: first-in-man study

Krause, Korff; Jaquet, Kai; Schneider, Carsten; S, Haupt; Mv, Lioznov; Km, Otte; Kh, Kuck

doi:10.1136/hrt.2008.155077

Cited by 77 publications

(50 citation statements)

References 39 publications

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“…Depurated skills supported by an appropriate knowledge of the morphology of these structures are required to perform several procedures such as catheterisation, stenting, bypassing, and perfusion of substances with physiological or pharmacological effects (Kang et al 2006, Krause et al 2009, Van Slochteren et al 2016. Therefore, due to the similarity of its coronary circulation, the heart of the horse is an excellent procedural model that allows for perfecting such techniques.…”

Section: Discussionmentioning

confidence: 99%

Morphologic expression of the right coronary artery in horses. Comparative description with humans, pigs and other animal species

Gómez

Ballesteros

Estupiñán

2017

Austral j. vet. sci.

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ABSTRACT. The objective of this research was to characterise morphologically the right coronary artery and its branches in the horse. The right coronary arteries of 120 horse hearts were perfused with semi-synthetic resin (85% Palatal GP40L; 15% styrene) and mineral red dye. The morphological and biometric characteristics of the right coronary artery and its branches (digital calibrator) were assessed. The diameter of the right coronary artery was 6.72 ± 2.58 mm. The interventricular subsinusal branch ended at the apex in 94 specimens (78.4%). The right circumflex branch originated at the site of intersection of the subsinnusal interventricular sulcus and the atrioventricular septum, extended along the coronary sulcus with a convoluted trajectory, ended at the obtuse edge of the heart or even at the anterior aspect of the left ventricle in 62 hearts (52.5%), and at the middle segment of the left ventricle in 42 cases (35.6%), whereas in 14 samples (11.9%) it ended at the adjacent surface of the left ventricle. The right conus branch was found in 98 specimens (81.6%) and in 2 of them (1.7%) it emerged directly from the right aortic sinus (third coronary artery). The hearts exhibited right coronary dominance in 118 specimens (98.3%) and in 2 specimens (1.7%) the coronary dominance was balanced. No myocardial bridges were observed. The high incidence of right coronary dominance observed in this study is consistent with previous studies. Due to its similarity with the human heart, we may ratify the equine model for procedural and hemodynamic applications.Key words: horse, coronary artery, dominance, heart.RESUMEN. El objetivo de esta investigación fue caracterizar morfológicamente la arteria coronaria derecha del caballo y sus ramas. En 120 corazones de caballo se perfundieron las arterias coronarias derechas con resina semisintética (palatal GP40L al 85%; estireno al 15%) y color rojo mineral. Se evaluó las características morfológicas y biométricas de la arteria coronaria derecha y sus ramas (calibrador digital). El diámetro de la arteria coronaria derecha fue 6,72 +/-2,58 mm. La rama interventricular subsinusal finalizó en el ápex en 94 especímenes (78,4%). La rama circunfleja derecha se originó a nivel del sitio de cruce del surco interventricular subsinusal y el septum atrioventricular, se extendió a lo largo del surco coronario con una trayectoria contorneada y finalizando en el borde obtuso del corazón o incluso en la cara anterior del ventrículo izquierdo en 62 corazones (52,5%) y en el segmento medio del ventrículo izquierdo en 42 casos (35,6%), mientras que en 14 muestras (11,9%) esta finalizó en la superficie adyacente del ventrículo izquierdo. La rama derecha del cono, se encontró en 98 especímenes (81,6%) y en 2 corazones (1,7%) emergió directamente del seno aórtico derecho (tercera coronaria). Los corazones presentaron dominancia coronaria derecha en 118 muestras (98,3%) y en 2 casos (1,7%) la dominancia coronaria fue balanceada. No se observó puentes miocárdicos. La alta incidencia de dominancia coron...

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Section: Discussionmentioning

confidence: 99%

Morphologic expression of the right coronary artery in horses. Comparative description with humans, pigs and other animal species

Gómez

Ballesteros

Estupiñán

2017

Austral j. vet. sci.

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“…27, Many demonstrated improvement in EF, 27,[44][45][46][47][48][49][50][51][52]55,56,59,61 volumes, 27,[43][44][45]47,48,[50][51][52]59 wall motion, [43][44][45][47][48][49] and infarct size [43][44][45]47,54,61 when compared with conventional treatment. REPAIR-AMI showed decreased mortality, recurrent AMI, and HF re-hospitalizations, 51 with maintained improvement at two years.…”

Section: Clinical Outcomes Acute Myocardial Infarctionmentioning

confidence: 99%

Stem Cell Therapy for Heart Disease

2013

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Coronary artery disease is the leading cause of death in Americans. After myocardial infarction, significant ventricular damage persists despite timely reperfusion and pharmacological management. Treatment is limited, as current modalities do not cure this damage. In the past decade, stem cell therapy has emerged as a promising therapeutic solution to restore myocardial function. Clinical trials have demonstrated safety and beneficial effects in patients suffering from acute myocardial infarction, heart failure, and dilated cardiomyopathy. These benefits include improved ventricular function, increased ejection fraction, and decreased infarct size. Mechanisms of therapy are still not clearly understood. However, it is believed that paracrine factors, including stromal cell-derived factor-1, contribute significantly to stem cell benefits. The purpose of this article is to provide medical professionals with an overview on stem cell therapy for the heart and to discuss potential future directions.

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“…An example is the study by Krause et al who utilized percutaneous intramyocardial injection on 20 patients with AMI. No adverse procedural effects were reported and an initial improvement in LVEF within the first 6 months was seen (Krause et al, 2009). The ESI is still in a preclinical stage, but has shown successful cell transplantation and significant LVEF improvement in a porcine model of MI (Wei et al, 2010).…”

Section: Routes Of Administrationmentioning

confidence: 99%

Stem cell therapy for cardiovascular disease: the demise of alchemy and rise of pharmacology

Jadczyk

Faulkner

Madeddu

2013

British J Pharmacology

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Regenerative medicine holds great promise as a way of addressing the limitations of current treatments of ischaemic disease. In preclinical models, transplantation of different types of stem cells or progenitor cells results in improved recovery from ischaemia. Furthermore, experimental studies indicate that cell therapy influences a spectrum of processes, including neovascularization and cardiomyogenesis as well as inflammation, apoptosis and interstitial fibrosis. Thus, distinct strategies might be required for specific regenerative needs. Nonetheless, clinical studies have so far investigated a relatively small number of options, focusing mainly on the use of bone marrow-derived cells. Rapid clinical translation resulted in a number of small clinical trials that do not have sufficient power to address the therapeutic potential of the new approach. Moreover, full exploitation has been hindered so far by the absence of a solid theoretical framework and inadequate development plans. This article reviews the current knowledge on cell therapy and proposes a model theory for interpretation of experimental and clinical outcomes from a pharmacological perspective. Eventually, with an increased association between cell therapy and traditional pharmacotherapy, we will soon need to adopt a unified theory for understanding how the two practices additively interact for a patient's benefit. LINKED ARTICLESThis article is part of a themed section on Regenerative Medicine and Pharmacology: A Look to the Future. To view the other articles in this section visit http://dx

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Percutaneous intramyocardial stem cell injection in patients with acute myocardial infarction: first-in-man study

Abstract: Eudra-CT-No 2005-003629-19.

Cited by 77 publications

References 39 publications

Morphologic expression of the right coronary artery in horses. Comparative description with humans, pigs and other animal species

Morphologic expression of the right coronary artery in horses. Comparative description with humans, pigs and other animal species

Stem Cell Therapy for Heart Disease

Stem cell therapy for cardiovascular disease: the demise of alchemy and rise of pharmacology

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