Percutaneous Intraportal Islet Cell Infusion for Islet Autotransplant After Pancreatectomy: How I Do It

Lewellen, Kyle A.; Haste, Paul; Zyromski, Nicholas J.

doi:10.1007/s11605-023-05781-y

Journal of Gastrointestinal Surgery

2023

DOI: 10.1007/s11605-023-05781-y

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Percutaneous Intraportal Islet Cell Infusion for Islet Autotransplant After Pancreatectomy: How I Do It

Kyle A. Lewellen¹,

Paul Haste²,

Nicholas J. Zyromski³

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2024

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Total Pancreatectomy With Percutaneous Islet Autotransplant After Remote Islet Processing

Lewellen,

Maatman,

House

et al. 2024

Pancreas

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Objectives Total pancreatectomy with islet autotransplant (TPIAT) is important therapy for select chronic pancreatitis (CP) patients. The specialized technique of islet isolation limits widespread TPIAT use. We hypothesized that remote islet isolation provides satisfactory islet yield and perioperative outcomes. Methods Retrospective review of TPIAT patients between 2020 and 2022. Islet isolation was performed off-site, with percutaneous intraportal islet autotransplant (IAT) completed the morning following pancreatectomy. Demographics and perioperative outcomes were analyzed. Results Fourteen patients underwent TPIAT; median age was 43 [interquartile range 12.5] years. Operation occurred 7.5 [14.8] years after pancreatitis diagnosis. The most common pancreatitis etiology was genetic (50%). All patients underwent preoperative endoscopic therapy; three underwent prior pancreatectomy. Operative time was 236 [51] minutes; subsequent percutaneous IAT time was 87 [35] minutes. The islet equivalent (IEQ)/kilogram (kg) yield was 3,456 [3,815] IEQ/kg. Nine patients had positive islet cultures. Two thromboembolic events and one bacteremia occurred. One perihepatic hematoma occurred after percutaneous portal venous access. Median postoperative length of stay was 14.5 days, and five patients (36%) were readmitted within 90 days. All patients were discharged home on insulin. No mortality occurred. Conclusion Total pancreatectomy with remote islet isolation provides excellent islet yield for autotransplant and satisfactory perioperative outcomes.

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Total Pancreatectomy With Percutaneous Islet Autotransplant After Remote Islet Processing

Lewellen,

Maatman,

House

et al. 2024

Pancreas

View full text Add to dashboard Cite

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Percutaneous Intraportal Islet Cell Infusion for Islet Autotransplant After Pancreatectomy: How I Do It

Cited by 1 publication

References 3 publications

Total Pancreatectomy With Percutaneous Islet Autotransplant After Remote Islet Processing

Total Pancreatectomy With Percutaneous Islet Autotransplant After Remote Islet Processing

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