Percutaneous Irreversible Electroporation of a Large Centrally Located Hepatocellular Adenoma in a Woman with a Pregnancy Wish

Scheffer, Hester J.; Melenhorst, Marleen C.A.M.; Tilborg, Aukje A. J. M. van; Nielsen, Karin; Nieuwkerk, Karin M. van; Vries, Richard A. de; Tol, Paul; Meijerink, Martijn R.

doi:10.1007/s00270-014-1041-8

Cited by 12 publications

(6 citation statements)

References 21 publications

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“…PEF treatment has dramatically improved gene-transfer efficiencies in tissues such as liver, skin, and skeletal muscle [22,38,39,40]. IRE technology has been used to treat tumors in canine brain tissue [41], human and porcine liver tissue [42,43,44,45], and and human and porcine pancreatic tissue [46,47,48]. By destroying malignant cells while mitigating damage to critical stromal tissue components [49,50], it enables the treatment of tissues around critical structures that would otherwise render the site untreatable.…”

Section: Introductionmentioning

confidence: 98%

Quantification of cell membrane permeability induced by monopolar and high-frequency bipolar bursts of electrical pulses

Sweeney

Reberšek

Dermol

et al. 2016

Biochimica et Biophysica Acta (BBA) - Biomembranes

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High-frequency bipolar electric pulses have been shown to mitigate undesirable muscle contraction during irreversible electroporation (IRE) therapy. Here, we evaluate the potential applicability of such pulses for introducing exogenous molecules into cells, such as in electrochemotherapy (ECT). For this purpose we develop a method for calculating the time course of the effective permeability of an electroporated cell membrane based on real-time imaging of propidium transport into single cells that allows a quantitative comparison between different pulsing schemes. We calculate the effective permeability for several pulsed electric field treatments including trains of 100μs monopolar pulses, conventionally used in IRE and ECT, and pulse trains containing bursts or evenly-spaced 1μs bipolar pulses. We show that shorter bipolar pulses induce lower effective membrane permeability than longer monopolar pulses with equivalent treatment times. This lower efficiency can be attributed to incomplete membrane charging. Nevertheless, bipolar pulses could be used for increasing the uptake of small molecules into cells more symmetrically, but at the expense of higher applied voltages. These data indicate that high-frequency bipolar bursts of electrical pulses may be designed to electroporate cells as effectively as and more homogeneously than conventional monopolar pulses.

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Section: Introductionmentioning

confidence: 98%

Quantification of cell membrane permeability induced by monopolar and high-frequency bipolar bursts of electrical pulses

Sweeney

Reberšek

Dermol

et al. 2016

Biochimica et Biophysica Acta (BBA) - Biomembranes

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“…Integral muscle relaxation is also essential which implies the use of curare and by definition, general anesthesia. Limited severe collateral damage has been seen to date in patients generally selected on the basis of tumor sites deemed to be ''at risk'' for the other thermal methods [7,8].…”

Section: Electroporation: When Thermo-ablation Is Too Riskymentioning

confidence: 99%

Ablative therapies: Advantages and disadvantages of radiofrequency, cryotherapy, microwave and electroporation methods, or how to choose the right method for an individual patient?

Séror

2015

Diagnostic and Interventional Imaging

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Several ablation techniques are currently available. Except for electroporation, all of these methods cause fatal damage at a cellular level and irreversible architectural deconstruction at a tissue level by thermal effects. Ablation of a tumor using one of these techniques, whether thermal or otherwise, requires applicators to be positioned from which the energy is delivered in situ. Some techniques, however, require several applicators to be inserted (multibipolar radiofrequency, cryotherapy and electroporation) whereas a single applicator is often sufficient with other technologies (monopolar radiofrequency and microwave). These methods are conceptually very similar but are distinguished from each other in practice through the technologies they use. It is essential to understand these differences as they influence the advantages and limitations of each of the techniques. There is no such thing as the perfect multifunctional ablation device and choice is dictated on an individual patient basis depending on the aim of treatment, which itself depends on each patient's clinical situation.

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“…32 There are limited reports regarding the ablative effects of HCA (Table 6). [33][34][35][36][37] Rocourt et al 33 reported a 13-year-old patient in whom a liver tumor measuring 35 mm was incidentally detected and was histologically diagnosed as adenoma by percutaneous biopsy. 33 Because of the relatively small lesion, RFA was selected as the treatment of choice.…”

Section: Hepatocellular Adenoma (Hca)mentioning

confidence: 99%

Ablation for Benign Liver Tumors: Current Concepts and Limitations

Maruyama¹,

Tobari²,

Nagamatsu³

et al. 2022

J Clin Transl Hepatol

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Percutaneous ablation under imaging guidance is a curative treatment that can induce complete tumor necrosis with advantages of minimal invasiveness and a low risk of complications. Thermal ablation, which includes radiofrequency ablation and microwave ablation, is a representative technique that has sufficient antitumor effects in cases of hepatocellular carcinoma with ≤3 lesions measuring ≤3 cm and preserved liver function. The short-and long-term outcomes of patients are comparable with those achieved with surgical resection. Despite their nonmalignant nature, some benign liver tumors require treatment for symptoms caused by the presence of the tumor and/or continuous enlargement. Ablation may be the treatment of choice because it has lower burden on patients than surgical treatment. This review describes the recent concepts, progress, and limitations of ablation-based treatment for benign liver tumors.

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Percutaneous Irreversible Electroporation of a Large Centrally Located Hepatocellular Adenoma in a Woman with a Pregnancy Wish

Cited by 12 publications

References 21 publications

Quantification of cell membrane permeability induced by monopolar and high-frequency bipolar bursts of electrical pulses

Quantification of cell membrane permeability induced by monopolar and high-frequency bipolar bursts of electrical pulses

Ablative therapies: Advantages and disadvantages of radiofrequency, cryotherapy, microwave and electroporation methods, or how to choose the right method for an individual patient?

Ablation for Benign Liver Tumors: Current Concepts and Limitations

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