Percutaneous microwave coagulation therapy for solitary metastatic liver tumors from colorectal cancer: a pilot clinical study

Seki, Toshihito; Wakabayashi, Masayuki; Nakagawa, Taiichi; Imamura, Masato; Tamai, Toru; Nishimura, Akira; Yamashiki, Noriyo; Inoue, Katsumi

doi:10.1016/s0002-9270(98)00730-8

Cited by 31 publications

(41 citation statements)

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“…Local ablative techniques that result in intrahepatic tumor destruction have emerged as alternative treatment options, although positive effects on patients' survival remain to be established. These techniques include microwave tumor coagulation (19), laser-induced thermotherapy (20), injection of ethyl alcohol (21), cryosurgical ablation or cryotherapy (CSA) (22), and radiofrequency ablation (RFA) (23).…”

Section: Monitoring Responses After Local Ablative Therapy Of Liver Mmentioning

confidence: 99%

Monitoring and Predicting Response to Therapy with ¹⁸F-FDG PET in Colorectal Cancer: A Systematic Review

Geus-Oei¹,

Vriens²,

Laarhoven³

et al. 2009

J Nucl Med

197

131

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Molecular imaging with 18 F-FDG PET has been proven useful in the management of colorectal cancer. 18 F-FDG PET plays a pivotal role in staging before surgical resection of recurrent colorectal cancer and metastases, in the localization of recurrence in patients with an unexplained rise in serum carcinoembryonic antigen levels, and in the assessment of residual masses after treatment. Currently, there is increasing interest in the role of 18 F-FDG PET beyond staging. The technique appears to have significant potential for the characterization of tumors and for the prediction of prognosis in the context of treatment stratification and early assessment of tumor response to therapy. This systematic review provides an overview of the literature on the value of 18 F-FDG PET for monitoring and predicting the response to therapy in colorectal cancer. The review covers chemotherapy response monitoring in advanced colorectal cancer, monitoring of the effects of local ablative therapies, and preoperative radiotherapy and multimodality treatment response evaluation in primary rectal cancer. Given the added value of 18 F-FDG PET for these indications, implementation in clinical practice and systematic inclusion in therapeutic trials to exploit the potential of 18 F-FDG PET are warranted.

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Section: Monitoring Responses After Local Ablative Therapy Of Liver Mmentioning

confidence: 99%

Monitoring and Predicting Response to Therapy with ¹⁸F-FDG PET in Colorectal Cancer: A Systematic Review

Geus-Oei¹,

Vriens²,

Laarhoven³

et al. 2009

J Nucl Med

197

131

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“…Heat ablation of liver tumors can also be performed using microwave coagulation therapy or laser-induced thermotherapy [45][46][47]. Like RFA, these procedures can be performed during an open laparotomy, with laparoscopic or thoracoscopic guidance, or percutaneously.…”

Section: Greatest Diametermentioning

confidence: 99%

“…The effectiveness of these treatments is currently limited by the small zones of necrosis achieved with the rapid heating and desiccation of the tissue around the microwave or laser probes. Multiple insertions of the probes are required to treat tumors more than 1 cm in diameter with microwave coagulation therapy, or more than 2 cm in diameter with laser-induced thermal ablation [45][46][47]. Currently, the treatment complexity of placing multiple intratumoral probes and the cost for these microwave or laser systems (at least 10 times higher than RF generators and needle electrodes) are limiting the clinical utility of these alternative thermal ablation techniques.…”

Section: Greatest Diametermentioning

confidence: 99%

Radiofrequency Ablation of Malignant Liver Tumors

2001

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The majority of patients with primary or metastatic hepatic tumors are not candidates for resection because of tumor size, location near major intrahepatic blood vessels precluding a margin-negative resection, multifocality, or inadequate hepatic function related to coexistent cirrhosis. Radiofrequency ablation (RFA) is an evolving technology being used to treat patients with unresectable primary and metastatic hepatic cancers. RFA produces coagulative necrosis of tumor through local tissue heating. Liver tumors are treated percutaneously, laparoscopically, or during laparotomy using ultrasonography to identify tumors and guide placement of the RFA needle electrode. For tumors smaller than 2.0 cm in diameter, one or two deployments of the monopolar multiple array needle electrode are sufficient to produce complete coagulative necrosis of the tumor. However, with increasing size of the tumor, there is a concomitant increase in the number of deployments of the needle electrode and the overall time necessary to produce complete coagulative necrosis of the tumor. In general, RFA is a safe, well-tolerated, effective treatment for unresectable hepatic malignancies less than 6.0 cm in diameter. Effective treatment of larger tumors awaits the development of more powerful, larger array monopolar and bipolar RFA technologies.

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“…Percutaneous microwave coagulation therapy (PMCT) has been used for the local treatment of either hepatocellular carcinoma (HCC) or metastatic liver tumors (1)(2)(3)(4)(5). In previous studies, PMCT has demonstrated the feasibility of efficaciously treating small HCC measuring ≤2.0 cm in diameter with a 5-year survival rate of about 70% (3).…”

Section: Introductionmentioning

confidence: 99%

Percutaneous microwave coagulation therapy for hepatocellular carcinoma: Increased coagulation diameter using a new electrode and microwave generator

Inokuchi

Seki²,

Ikeda³

et al. 2010

Oncol Rep

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Abstract. We performed percutaneous microwave coagulation therapy (PMCT) using a new microwave electrode and microwave generator to lessen the number of microwave electrode insertions for hepatocellular carcinoma (HCC) measuring ≤3.0 cm in diameter. In this study, we assessed the efficacy of this new system. Fifty-two patients with liver cirrhosis and HCC measuring ≤3.0 cm in diameter (tumor size: ≤2 cm, 27 patients; >2 to ≤2.5 cm, 13 patients; >2.5 to ≤3 cm, 12 patients) underwent PMCT using a new microwave coagulation system under ultrasonographic guidance. Fortytwo of 52 patients showed complete necrosis of the tumor lesion with a treated margin ≥5 mm on dynamic computed tomography. Necrosis of HCC and the non-cancerous area surrounding the tumor was obtained by a single needle insertion in 23 patients (tumor size: ≤2 cm, 23 patients), by two needle insertions in 11 patients (tumor size: ≤2 cm, 4 patients; >2 to ≤2.5 cm, 5 patients; >2.5 to ≤3 cm, 2 patients), and by three needle insertions in 8 patients (tumor size: >2 to ≤2.5 cm, 5 patients; >2.5 to ≤3 cm, 3 patients). During the follow-up period of 5-34 months, all patients remained alive. Among the patients showing complete necrosis of HCC with a treated margin ≥5 mm, we have not detected local recurrences. On the other hand, 4 of the 10 patients who could not obtain the treated margin of ≥5 mm, experienced a local recurrence. No fatal complications were observed. However, bile duct stricture was observed in 2 patients. The new microwave coagulation system can induce extensive necrosis with a small number of microwave electrode insertions. This system may enhance the efficacy of PMCT for HCC measuring <3.0 cm in diameter.

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Percutaneous microwave coagulation therapy for solitary metastatic liver tumors from colorectal cancer: a pilot clinical study

Abstract: PMCT is a safe and effective treatment for metachronous small liver tumors that have metastasized from colorectal cancer.

Cited by 31 publications

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Monitoring and Predicting Response to Therapy with ¹⁸F-FDG PET in Colorectal Cancer: A Systematic Review

Monitoring and Predicting Response to Therapy with ¹⁸F-FDG PET in Colorectal Cancer: A Systematic Review

Radiofrequency Ablation of Malignant Liver Tumors

Percutaneous microwave coagulation therapy for hepatocellular carcinoma: Increased coagulation diameter using a new electrode and microwave generator

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Percutaneous microwave coagulation therapy for solitary metastatic liver tumors from colorectal cancer: a pilot clinical study

Abstract: PMCT is a safe and effective treatment for metachronous small liver tumors that have metastasized from colorectal cancer.

Cited by 31 publications

References 0 publications

Monitoring and Predicting Response to Therapy with 18F-FDG PET in Colorectal Cancer: A Systematic Review

Monitoring and Predicting Response to Therapy with 18F-FDG PET in Colorectal Cancer: A Systematic Review

Radiofrequency Ablation of Malignant Liver Tumors

Percutaneous microwave coagulation therapy for hepatocellular carcinoma: Increased coagulation diameter using a new electrode and microwave generator

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Product

Resources

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Monitoring and Predicting Response to Therapy with ¹⁸F-FDG PET in Colorectal Cancer: A Systematic Review

Monitoring and Predicting Response to Therapy with ¹⁸F-FDG PET in Colorectal Cancer: A Systematic Review