Percutaneous MR imaging-guided laser-induced thermotherapy of hepatic metastases

Mg, Mack; Straub, Roland; Eichler, Katrin; Engelmann, K.; Zangos, Stephan; Roggan, A.; Woitaschek, Dirk; Böttger, Marian; Vogl, Thomas

doi:10.1007/s002610000197

Cited by 96 publications

(68 citation statements)

References 16 publications

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“…Survival of treated patients is encouraging. Thus for patients with liver metastases of colorectal cancer, 2 and 5 year survival rates after LiTT of 74% and 30%, respectively, [2,3] , and a 2 year survival of 67% after RFA [6] were reported. These data are comparable with results of surgical resection that can lead to 2 and 5 year survival rates of 64% and 28%, respectively, and to disease free survival rates of 35 and 15% for patients with liver metastases of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Radio-frequency thermal ablation (RFA) is a common therapy option for unresectable liver tumors. Thus it was shown that RFA and laserinduced thermo-therapy (LiTT) can achieve survival times comparable to surgery in selected patients [1][2][3] . RFA uses a radio-frequency current to induce coagulation necrosis which results in a local thermal necrosis accompanied by Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases local inflammation around the necrotic center and by a hemorrhagic rim with lymphoplasmacellular infiltrates [4] .…”

Section: Introductionmentioning

confidence: 99%

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Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases

Hänsler

Wissniowski²,

Schuppan³

et al. 2006

WJG

116

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to 0.109 (± 0.005) for CD4 + and 0.11 (± 0.012) for CD8 + T cells against HCC, and to 0.115 (± 0.031) for CD4 + and 0.15 (± 0.02) for CD8 + cells for colorectal metastases (P < 0.0001). No increased SI was observed with nonmalignant tumor tissue at all time points. Before RFA cytolytic activity against the respective cancer cells was low with 2.62 (± 0.37) relative luminescence units (RLU), but rose more than 100 fold 4 and 8 wk after RFA. Spontaneous release was < 2% of maximum release in all experiments. CONCLUSION:Patients with primary and secondary tumors of the liver show a significant tumor-specific cytotoxic T-cell stimulation with a dramatically increased tumor specific cytolytic activity of CD8 + T cells after RFA. INTRODUCTIONOpen surgery is still the gold standard for the treatment of hepatocellular carcinoma (HCC) and liver metastases of colorectal cancer. However, more than 75% of these patients are non-resectable for various reasons, such as size and location of the tumor. Radio-frequency thermal ablation (RFA) is a common therapy option for unresectable liver tumors. Thus it was shown that RFA and laserinduced thermo-therapy (LiTT) can achieve survival times comparable to surgery in selected patients [1][2][3] . RFA uses a radio-frequency current to induce coagulation necrosis which results in a local thermal necrosis accompanied by Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases www

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases

Hänsler

Wissniowski²,

Schuppan³

et al. 2006

WJG

116

View full text Add to dashboard Cite

show abstract

“…Because there is no interference of the laser with the MR scanner, LITT is well suited for image-based thermal monitoring. Lesion sizes achieved with the laser are relatively small, but catheter cooled systems (5) are available that achieve larger lesion sizes.…”

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confidence: 99%

MR thermometry

Rieke

Pauly

2008

Magnetic Resonance Imaging

1,022

952

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Minimally invasive thermal therapy as local treatment of benign and malignant diseases has received increasing interest in recent years. Safety and efficacy of the treatment require accurate temperature measurement throughout the thermal procedure. Noninvasive temperature monitoring is feasible with magnetic resonance (MR) imaging based on temperature-sensitive MR parameters such as the proton resonance frequency (PRF), the diffusion coefficient (D), T 1 and T 2 relaxation times, magnetization transfer, the proton density, as well as temperature-sensitive contrast agents. In this article the principles of temperature measurements with these methods are reviewed and their usefulness for monitoring in vivo procedures is discussed. Whereas most measurements give a temperature change relative to a baseline condition, temperature-sensitive contrast agents and spectroscopic imaging can provide absolute temperature measurements. The excellent linearity and temperature dependence of the PRF and its near independence of tissue type have made PRF-based phase mapping methods the preferred choice for many in vivo applications. Accelerated MRI imaging techniques for real-time monitoring with the PRF method are discussed. Special attention is paid to acquisition and reconstruction methods for reducing temperature measurement artifacts introduced by tissue motion, which is often unavoidable during in vivo applications.

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“…Maximal tissue penetration and the desired therapeutic results are achieved by producing slow heating within its therapeutic window. Most studies with LITT have been reported in patients with liver metastases, with favorable survival rates and an acceptable complication profile [52,53] . A single trial of LITT for HCC evaluated the efficacy of a combination of TACE and LITT compared to TACE alone.…”

Section: Figure 2 Axial Computed Tomography Images Before and After Rmentioning

confidence: 99%

Locoregional treatment for hepatocellular carcinoma: The best is yet to come

Kalra

Gupta

Chawla

et al. 2015

WJR

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Percutaneous MR imaging-guided laser-induced thermotherapy of hepatic metastases

Abstract: In patients with liver metastases, local tumor destruction using minimally invasive, percutaneous LITT under local anesthesia results in improved clinical outcomes and survival rates and can be a potential alternative to surgical resection.

Cited by 96 publications

References 16 publications

Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases

Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases

MR thermometry

Locoregional treatment for hepatocellular carcinoma: The best is yet to come

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