Percutaneous Pelvic Perfusion with Extracorporeal Chemofiltration for Advanced Uterine Cervical Carcinoma

Adsorption of Doxorubicin on Poly(methyl methacrylate)–Chitosan–Heparin-Coated Activated Carbon Beads

“…1–5 Increased antitumor effects are generally believed to correlate with higher dose intensity, but are also associated with severe toxicity. 6 Doxorubicin (DOX) is a chemotherapy drug used in the treatment of a wide range of cancers including liver cancer. However, doxorubicin has significant side effects including, but not limited to, severe cardiac toxicity, damage to the immune system, acute nausea, severe vomiting, dermatological problems and hair loss.…”

“…Localized and targeted chemotherapeutic drug delivery could potentially deliver significantly higher doses of toxic anticancer drugs, directly to a tumor where it is required, decreasing systemic toxicity and improving drug efficacy and safety. Intra-arterial chemotherapy has recently been shown to result in remarkable clinical outcomes with minimal adverse effects, as compared to systemic administration, because of higher intratumoral concentrations of oncostatics. − Increased antitumor effects are generally believed to correlate with higher dose intensity but are also associated with severe toxicity . Doxorubicin (DOX) is a chemotherapy drug used in the treatment of a wide range of cancers, including liver cancer.…”

Pharmacokinetics and Disposition of a Localized Lymphatic Polymeric Hyaluronan Conjugate of Cisplatin in Rodents

“…Since nonspecific organ toxicities hamper CDDP chemotherapy, oncologists have developed procedures to confine chemotherapy to the diseased areas by temporarily isolating the affected tissues or organs from the systemic circulation and perfusing them with CDDP. For example, intraarterial percutaneous pelvic perfusion of high‐dose CDDP has demonstrated a therapeutic advantage in advanced uterine cervical carcinoma8 while achieving a low side‐effect profile. However, these treatments are highly invasive and require specialized skills and equipment usually restricted to large medical research centers.…”

Spectral CT imaging in cervical computed tomography angiography: comparison of spectral CT monochromatic imaging and conventional CT polychromatic imaging

“…1 Therefore, careful assessment of the artery network supplying the cervical cancer tumours in each patient is essential in planning surgical treatment and arterial chemotherapy. 2 Computed tomography angiography (CTA) is a minimally invasive procedure for the visualisation of vascular structures. Increasing the dose of contrast agent can improve CTA image quality, but the contrast agent may cause contrast-induced nephropathy (CIN), and the incidence rate of CIN is related to the concentration, total iodine and osmolality of the contrast agent.…”

“…Neoadjuvant chemotherapy, especially transcatheter arterial chemotherapy, is an effective adjuvant therapeutic tool to improve the postoperative survival rate when treating intermediate and advanced stage cervical cancers . Therefore, careful assessment of the artery network supplying the cervical cancer tumours in each patient is essential in planning surgical treatment and arterial chemotherapy . Computed tomography angiography (CTA) is a minimally invasive procedure for the visualisation of vascular structures.…”