2019
DOI: 10.1093/milmed/usz114
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Percutaneous Peripheral Nerve Stimulation for the Treatment of Chronic Pain Following Amputation

Abstract: Introduction Chronic pain and reduced function are significant problems for Military Service members and Veterans following amputation. Peripheral nerve stimulation (PNS) is a promising therapy, but PNS systems have traditionally been limited by invasiveness and complications. Recently, a novel percutaneous PNS system was developed to reduce the risk of complications and enable delivery of stimulation without surgery. Materials and Methods … Show more

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Cited by 45 publications
(26 citation statements)
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“…A multicenter, randomized, double-blind, placebo-controlled trial was conducted to evaluate changes in chronic pain and functional outcomes following amputation up to 12 months after a 60-day PNS treatment. Post-amputation pain, including residual limb pain (RLP) and phantom limb pain (PLP), is commonly neuropathic in origin, though RLP may also have non-neuropathic etiologies 11. The primary endpoint of the study was previously reported to be positive, finding that a greater proportion of participants receiving 4 weeks of PNS reported substantial (≥50%) reductions in pain compared with those receiving 4 weeks of placebo to a statistically significant degree 12.…”
Section: Introductionmentioning
confidence: 99%
“…A multicenter, randomized, double-blind, placebo-controlled trial was conducted to evaluate changes in chronic pain and functional outcomes following amputation up to 12 months after a 60-day PNS treatment. Post-amputation pain, including residual limb pain (RLP) and phantom limb pain (PLP), is commonly neuropathic in origin, though RLP may also have non-neuropathic etiologies 11. The primary endpoint of the study was previously reported to be positive, finding that a greater proportion of participants receiving 4 weeks of PNS reported substantial (≥50%) reductions in pain compared with those receiving 4 weeks of placebo to a statistically significant degree 12.…”
Section: Introductionmentioning
confidence: 99%
“…A fabric antenna can then be worn in regular clothing or using certain accessories that can fit different body parts. None of our patients complained of difficulties associated with the wearable fabric antenna .…”
Section: Discussionmentioning
confidence: 86%
“…Peripheral nerve stimulation (PNS) is an advantageous form of neuromodulation that provides more selective stimulation and analgesia, as well as less procedural invasiveness, compared to traditional spinal cord stimulation (SCS). With the introduction of novel, commercially available, percutaneous systems, PNS is re-emerging as a useful therapy for neuropathic pain (2,3). This modality utilizes electrodes adjacent to peripheral nerves to treat painful conditions such as peripheral neuropathic pain and complex regional pain syndrome (CRPS) (4).…”
Section: To the Editormentioning
confidence: 99%
“…This modality utilizes electrodes adjacent to peripheral nerves to treat painful conditions such as peripheral neuropathic pain and complex regional pain syndrome (CRPS) (4). Recent research including a multicenter, randomized, controlled trial (RCT) has shown the effectiveness of PNS for lower extremity post-amputation pain (2,3,5). These studies have shown improvement in both PLP and RLP, which makes this modality attractive for use with amputees.…”
Section: To the Editormentioning
confidence: 99%