Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation†

Lu, David; Yu, Nam C.; Raman, Steven S.; Lassman, Charles; Tong, Myron J.; Britten, Carolyn D.; Durazo, Francisco; Saab, Sammy; Han, Steven; Finn, Richard S.; Hiatt, Jonathan R.; Busuttil, Ronald W.

doi:10.1002/hep.20688

Cited by 326 publications

(239 citation statements)

References 48 publications

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“…Therefore, the effect of pre-LT therapy on HCC and the outcome of LT for HCC, especially within the Milan criteria, have been reported with mixed results. [8][9][10][11][12][13][14][15] EGUCHI et al…”

Section: Introductionmentioning

confidence: 99%

Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation

et al. 2009

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“…However, only two studies provided data about the effectiveness of RFA in avoiding patients' drop out from LT waiting list due to tumor progression. The rate has been found to be 0% in one study [25] and 12% in another one [26].…”

Section: Radiofrequency Thermal Ablationmentioning

confidence: 86%

Bridge Treatments for HCC in the Waiting List for Liver Transplantation

Pompili¹,

Abbate²,

Nicolardi³

et al. 2011

TOTRANSJ

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During the past years, several therapeutic procedures have been proposed as bridging treatments in patients with hepatocellular carcinoma waiting for liver transplantation. Resective surgery, transarterial chemoembolization, radiofrequency thermal ablation and percutaneous ethanol injection are the most experienced, with the aim to decrease the rate of drop-out from LT waiting list, and the risk of HCC recurrence after transplant. Indeed, for patients within the Milan criteria, a time on waiting list exceeding 6-12 months is a known risk factor of tumor progression and drop out. For this reason, the application of bridging treatments in these patients might be reasonable and several studies in recent years have documented their usefulness to control tumor progression before the transplant. However, the favourable impact of these treatments on post-transplant patients' survival is still under investigation and the available studies provide controversial results. Bridging therapies have also been used for the downstaging of tumors exceeding the conventional "Milan criteria". Some recent data regarding multimodal sequential therapies seem to report promising results in terms of overall and disease-free survival of treated patients attaining effective downstaging before transplant.

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“…Essa técnica, apropriada para pacientes com reserva funcional hepática adequada (Child A ou B) e nódulos de localização segura e acessível, apresenta alta efi cácia na destruição do tumor. No exame dos explantes de 52 pacientes com 87 nódulos tumorais submetidos a essa técnica constatou-se necrose coagulativa completa de 74 dos 87 nódulos (85%) (15) . Nesse estudo o emprego da ablação por radiofreqüência resultou na exclusão de apenas 3 dos 52 (5,8%) pacientes com HCC, acompanhados por média de 12,7 meses em lista.…”

Section: Discussionunclassified

Resultados do transplante hepático em pacientes com diagnóstico pré-operatório de hepatocarcinoma

Parolin

Coelho

Matias

et al. 2006

Arq. Gastroenterol.

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Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation†

Abstract: Orthotopic liver transplantation (OLT) can be a definitive treatment for patients with hepatocellular carcinoma (HCC).

Cited by 326 publications

References 48 publications

Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation

Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation

Bridge Treatments for HCC in the Waiting List for Liver Transplantation

Resultados do transplante hepático em pacientes com diagnóstico pré-operatório de hepatocarcinoma

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