Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma: Effect of Histologic Grade on Therapeutic Results

Abstract

The histologic grade of HCC is an important factor influencing therapeutic results with survival after radiofrequency ablation.

Radiofrequency ablation of high-grade dysplastic nodules in chronic liver disease: comparison with well-differentiated hepatocellular carcinoma based on long-term results

“…However, there are no reports on the therapeutic efficacy of RF ablation for the treatment of high-grade DNs. RF ablation is widely used as a safe and effective treatment of malignant tumors, especially HCCs [10,[24][25][26]. In this study, percutaneous RF ablation is a very effective technique for treating high-grade DNs with 100 % technique effectiveness without local tumor progression during the mean follow-up period of 42 months.…”

Systematic review and meta-analysis of survival and disease recurrence after radiofrequency ablation for hepatocellular carcinoma

“…The rate of successful complete tumour ablation, as measured by non-enhancement of the tumour during contrast-enhanced computed tomography, is dependent mainly on its size 58 . The local tumour recurrence rate after RFA can be up to 50 per cent 77,78 , and is directly related to inability to ablate a larger lesion completely. Rhim and colleagues 79 reported a complete ablation rate of 96·7 per cent for HCC and a 5-year survival rate of 58 per cent.…”

Grading of small hepatocellular carcinomas (≤2 cm): correlation between histology,T2and diffusion-weighted imaging

“…5,6 Considering that histological confirmation of small suspicious hepatic nodules before treatment is often not possible owing to their location in the liver or the risks of track seeding, the role of a non-invasive pre-operative imaging technique for the discrimination of moderate to poorly differentiated HCCs from welldifferentiated HCCs is important. Diffusion-weighted imaging (DWI) allows the characterization of microscopic proton displacement and has profoundly improved oncological imaging.…”