Percutaneous Toxicokinetics of Hydrazine and H-70 in the Rabbit

Toxicokinetics of Hydrazine Administered Percutaneously to the Rabbit

“…More recent research has been done concerning the percutaneous absorption of Hz in the rabbit (Keller et al, 1981) and this report relates the results of the initial phase of our study. It describes the skin absorption of Hz from a 70% Hz aqueous solution (H-70, used in the F-16 EPU) and from anhydrous Hz.…”

“…This study was accomplished in three parts: part one, reported previously (Keller et al, 1981), in which one group of rabbits received Hz intravenously, and two groups were percutaneously treated with Hz either as anhydrous Hz or H-70; part two, in which three groups of rabbits were percutaneously exposed to anhydrous Hz and three groups to H-70 and exposures terminated at two, six, or twelve minutes post application (time-limited exposures); and, part three, in which two groups of rabbits were percutaneously exposed to aqueous solutions of either 15% or 2% Hz.…”

“…The method of animal preparation and administration of Hz or Hz solutions was identical to that of part one (Keller et al, 1981).…”

“…Those predictions of bioavailability and absorption rate were made by assuming evaporation and percutaneous absorption of Hz from anhydrous Hz and H-70 applied to skin to be competing, first order processes (Keller et al, 1981).…”

Urinary Metabolites of Hydrazine in Male Fischer 344 Rats Following Inhalation or Intravenous Exposure

“…The authors concluded that acute systemic toxicity correlated more closely with peak blood levels than with total amount absorbed (Keller et al, 1981). Keller et al (1984) later expanded this study to include the percutaneous absorption of hydrazine in the rabbit when exposures were time-limited and conducted with more dilute aqueous solutions.…”