Background: Transradial access (TRA) for percutaneous coronary procedures has become a widely adopted approach, with proven safety and feasibility. However, the trans-ulnar access (TUA) remains a promising alternative. This study aimed to compare radial and ulnar approach for percutaneous coronary procedures as regard feasibility, safety, and incidence of complications. Methods: This cross sectional comparative study was conducted at the Cardiology Department Cath lab of Benha University Hospitals & National Heart Institute. One hundred patients were included, with 50 patients in the TRA group and 50 patients in the TUA group. Inclusion and exclusion criteria were defined. Various clinical and procedural parameters, including access techniques, were meticulously recorded. Hemostasis was achieved with external compression with the TR band. The study assessed immediate post-procedure complications, so after removal of the TR band and before hospital discharge, all patients were examined postprocedure for potential access-site complications, arterial occlusion was examined clinically and by reversed Barbeau test. Results: The study revealed no statistically significant differences between the TRA and TUA groups in terms of patient demographics, procedural success, duration, fluoroscopy time, and procedure type. There were also no significant disparities in the affected vessel and the number of deployed stents. However, there was a statistically significant increase in the percentage of spasm in patients with TRA (24%) compared to TUA (8%). Conversely, patients with TUA experienced a statistically significant increase in the incidence of hematoma (18%) compared to TRA (4%). Conclusion: TRA has emerged as the prevailing method of access for coronary procedures due to its comparable efficacy and elevated safety profile. Both TRA and TUA approaches were considered safe and feasible for percutaneous coronary procedures. On the other hand, in terms of minor complications, arterial spasm and occlusion were more commonly observed with the TRA, so the TUA remains a promising alternative & proved to be noninferior to the TRA for coronary procedures.