Percutaneous Transluminal Mitral Commissurotomy in Nepalese children with Rheumatic Mitral Stenosis

Shrestha, Manish; Adhikari, Chandra Mani; Shakya, Urmila; Khanal, Aayush; Shrestha, Shradha; Rajbhandari, Rajib

doi:10.3126/njh.v10i1.9743

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…The growth posi vity rate diff ers depending on the sample size and the me period of the study. Similar previous studies from home and abroad have reported the growth posi vity varying from 5% to 70% 10,11,12 . In our study growth posi vity rate was high among male neonates (52.17%) than female neonates (47.82%) (p>0.05).Similar fi nding were reported from various places 12,13,14 .…”

Section: Discussionsupporting

confidence: 69%

Bacteriological Profile of Neonatal Sepsis in a Tertiary Level Hospital of Nepal

Khanal

Manandhar²,

Acharya

2015

J. Nepal Paedtr. Soc.

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Introduction: Neonatal sepsis is one of the most common reasons for admission to neonatal units in developing countries. It is also a major cause of mortality in both developed and developing countries. This study was done to determine the bacterial profile causing neonatal sepsis and to assess their susceptibility pattern to various antimicrobial agents. Materials and Methods: A cross-sectional prospective study was conducted in Paropakar Maternity and Women’s Hospital, Kathmandu, Nepal among 340 neonates suspected of neonatal sepsis. Blood culture was performed and organisms were identified with Gram staining and conventional biochemical methods. Antimicrobial susceptibility testing was performed by Kirby-Bauer disk diffusion method according to the Clinical and Laboratory Standards Institute (CLSI). Results: The prevalence rate of neonatal sepsis was 20.3%. Among 340 neonates, 52.17% were males and 47.82% were females. Gram positive cocci were the most predominant isolates (88.40%). Among Gram positive cocci Staphylococcus epidermidis was the most common isolates (72.46%) followed by Staphylococcus aureus (7.24%), Staphylococcus saprophyticus (4.34%) and Enterococcus fecalis (4.34%). Gram negative bacilli were found in 11.60% of the growth positive samples of which E.coli and Klebsiella spp were found in 10.14% and 1.44% respectively. Sensitivity to Amikacin was highest among all types of organisms isolated. Vancomycin and Gentamycin sensitivity was highest for Gram positive and Gram negative organisms respectively. Ampicillin resistance was highest among isolates. Among the 69 isolates 48 were Multiple drug resistant. Conclusion: The predominance of Gram positive cocci particularly Coagulase negative Staphylococci is shown. Empirical antibiotic therapy should be reviewed for Multiple drug resistant strains. DOI: http://dx.doi.org/10.3126/jnps.v34i3.9183 J Nepal Paediatr Soc 2014;34(3):175-180

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Section: Discussionsupporting

confidence: 69%

Bacteriological Profile of Neonatal Sepsis in a Tertiary Level Hospital of Nepal

Khanal

Manandhar²,

Acharya

2015

J. Nepal Paedtr. Soc.

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“…In a study conducted by Shrestha et al 8 procedural success rate of PBMV in patients below 15 years of age was 94%, similarly a study conducted in elderly by Adhikari et al 9 showed success rate of 83.6%. However, all of these studies were retrospective.…”

Section: Discussionmentioning

confidence: 89%

“…8,9 Looking at the burden of disease and the result of retrospective studies, we aim to carry out a prospective study to assess the safety, efficacy and outcome of PBMV.…”

Section: Introductionmentioning

confidence: 99%

Immediate Outcome of Percutaneous Balloon Mitral Valvotomy in Shahid Gangalal National Heart Centre, Bansbari, Kathmandu, Nepal

et al. 2015

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“…11,12,13 PTMC has been performed regularly in Shahid Gangalal National Heart Centre for the last 17 years. 14,15,16 Till now there is no data regarding the impact of PTMC on the RV function in our population. Thus we aim to study the impact of PTMC on RV function.…”

Section: Introductionmentioning

confidence: 96%

Immediate impact of percutaneous transvenous mitral commissurotomy on right ventricular function

Malla

Shah

et al. 2017

Nepalese Heart J.

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Background and Aims: Abnormal Right Ventricular (RV) function affects the long term outcome and clinical symptoms in patients with mitral stenosis (MS). This study evaluates the immediate effect of Percutaneous Transmitral Commisurotomy (PTMC) on RV function. Methods: An observational, cross sectional study was done on 50 patients with rheumatic MS who underwent PTMC at Shahid Gangalal National Heart Center from Dec 2015 -Dec 2016. All underwent clinical evaluation and echocardiogram before and immediately after PTMC. Results: There was female preponderance with 66% being female. The mean age was 37.26 ± 10.63 years. There was immediate increase in the mitral valve area (MVA) from 0.87 ± 0.12cm2 to 1.54 ± 0.27cm2(p< 0.001). There was significant decrease in mean mitral diastolic gradient from 16.4 ± 8.8mmHg to 5 ± 1.5mmHg (p< 0.001), in the pulmonary artery systolic pressure 53.6 ± 21.83mmHg to 39.5 ± 14.67mmHg (p< 0.001), in the RV Tei index from 0.56 ± 0.08 to 0.40 ± 0.08 (p< 0.001). There was significant increase in TAPSE from 16.0 ± 1.50 to 18.6 ± 1.70 mm, (p<0.001) and the longitudinal velocity of excursion of the RV at the tricuspid annulus (RV S') from 13.69 ± 3.33 cm/sec to 15.31 ± 3.07 cm/sec (p< 0.001) Conclusions: Successful PTMC can improve RV function as shown by the improvement in PASP, RV Tei index, TAPSE and RV S'. Further larger population studies are required to confirm the findings. Long term studies are important to determine the prognostic significance of improvement in RV function.

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Percutaneous Transluminal Mitral Commissurotomy in Nepalese children with Rheumatic Mitral Stenosis

Cited by 7 publications

References 10 publications

Bacteriological Profile of Neonatal Sepsis in a Tertiary Level Hospital of Nepal

Bacteriological Profile of Neonatal Sepsis in a Tertiary Level Hospital of Nepal

Immediate Outcome of Percutaneous Balloon Mitral Valvotomy in Shahid Gangalal National Heart Centre, Bansbari, Kathmandu, Nepal

Immediate impact of percutaneous transvenous mitral commissurotomy on right ventricular function

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