Percutaneous vertebroplasty in the treatment of vertebral body compression fracture secondary to osteogenesis imperfecta

Abstract

Percutaneous vertebroplasty, a minimally invasive interventional radiological procedure, has recently been used effectively for the treatment of symptomatic vertebral body compression fractures. Primary indications for vertebroplasty include osteoporotic compression fracture, osteolytic vertebral metastasis and myeloma, and vertebral hemangioma. We present a case and extend the indication of percutaneous vertebroplasty in a patient with a vertebral body compression fracture secondary to osteogenesis imperfecta.

Facet joint injections as a means of reducing the need for vertebroplasty in insufficiency fractures of the spine

“…Vertebral fractures resulting from minimal trauma are most commonly the result of osteoporosis, but maybe the consequence of osteoporosis induced by myeloma, myeloma deposits [1], metastatic malignant deposits in bone [2], haemangioma [3,4] and other rare disorders of bone including osteogenesis imperfecta [5]. Patients referred with a history of osteoporotic vertebral fracture may be considered for percutaneous treatment after they have undergone a period of conservative management [6].…”

Percutaneous vertebroplasty and balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures and osteolytic tumours

“…11 Percutaneous vertebroplasty was designed and introduced for the management of osteolytic tumours, [12][13][14][15] and later was successfully applied to osteoporotic vertebral compression fractures. 4,[16][17][18] It has also been shown to be valuable in the treatment of osteogenesis imperfecta, 19 and has been used for focal Paget's disease of the spine refractory to medical treatment. 20 The technique is well described in the literature.…”

The role of kyphoplasty in the management of osteogenesis imperfecta: risk or benefit?

“…Osteogenesis imperfecta is caused by a genetic defect of the gene that encodes type I collagen with the clinical manifestation of an inherited disorder of connective tissue. Characterized by abnormal osseous fragility leading to numerous fractures, the type I OI is the most common and mildest form and compatible with life [14].…”

“…Although there are some drawbacks in kyphoplasty, like extravasation of PMMA [11] with injury to the spinal cord or vascular structures or fractures of adjacent vertebrae [6], it is a minimal invasive technique with immediate therapeutic success. The authors identified six case reports [6,9,10,14,16,17] describing the treatment options of either vertebroplasty (five cases) or kyphoplasty (one case) in patients with OI ( Table 1). The reported drawbacks of vertebroplasty in OI [16,17] may be caused by the architecture of trabecular bone in this specific disease leading to an increasing risk of leaks, pulmonary embolism and resulting pulmonary and cardiac failure.…”

“…Painful vertebral compression fractures caused by osteoporosis or osteogenesis imperfecta (OI) are disease-related fractures and require an adequate treatment in order to relieve postural pain and restore activities of daily living [10,14]. Similar to patients suffering from severe osteoporosis, patients with OI are at risk to develop insufficiency fractures.…”