Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of acute and chronic dermatitis

Pinto, Nícolas de Castro Campos; Machado, Danielle Cunha; Silva, Josiane Mello da; Conegundes, Jéssica Leiras Mota; Gualberto, Ana Cristina Moura; Gameiro, Jacy; Chedier, Luciana Moreira; Castañon, Maria Christina Marques Nogueira; Scio, Elita

doi:10.1016/j.jep.2015.07.032

Cited by 78 publications

(57 citation statements)

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“…Furthermore, there are reports of the utilization of some species of the genus Pereskia as a natural medicine against cancer (Pinto et al, 2012). In the past five years, several biological activities have been attributed to P. aculeata leaf extracts, including in vivo topical anti-inflammatory activity in models of acute and chronic dermatitis (Pinto, Machado, et al, 2015), wound healing activity (Pinto et al, 2016) and antinociceptive activity (Pinto, Duque, et al, 2015), in vitro T antioxidant (Pinto et al, 2012;Sousa et al, 2014), and antimicrobial potentials (Souza et al, 2016), added to the antiproliferative activity against leukemia, neuroblastoma, and breast cancer cell lines (Pinto et al, 2012;Souza et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…In spite of the aforementioned studies evidencing the nutritional and ethnopharmacological relevance of ora-pro-nobis leaves, information on their phytochemical constitution remains limited. The majority of the papers that performed chemical evaluation contemplated the amino acids and phytosterol profiles, also focusing on its essential oil (Pinto & Scio, 2014;Pinto, Machado, et al, 2015;Souza et al, 2016;Zem, Helm, Henriques, Cabrini, & Zuffellato-Ribas, 2017). A few works have indicated that phenolic compounds and carotenoids are the major antioxidant constituents of P. aculeata leaves (Agostini-Costa, Wondraceck, Rocha, & Silva, 2012;Pinto et al, 2012;Pinto, Duque, et al, 2015), however, to our best knowledge, an advanced characterization of its phenolic constitution is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest

et al. 2019

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Pereskia aculeata Miller, known worldwide as ora-pro-nobis, is a highly nutritive species of the Cactaceae family from the Brazilian Atlantic Forest. In this work, we report inedited information on the phenolic profile of P. aculeata leaves, besides a broad study of their antioxidant potential using a set of five different methods. A total of ten phenolic compounds were identified, such as two phenolic acids (caffeic acid derivatives) and eight flavonoids (quercetin, kaempferol and isorhamnetin glycoside derivatives). Caftaric acid was the extract's major phenolic constituent, accounting for more than 49% of the phenolic content, followed by quercetin-3-O-rutinoside (14.99%) and isorhamnetin-O-pentoside-O-rutinoside (9.56%). Overall, the ora-pro-nobis leaf extract showed relevant values of antioxidant capacity, with higher activities than the Trolox in the DPPH and ABTS trials. The antimicrobial activity exhibited by the extract against both Gram-positive and Gram-negative bacteria suggests the presence of a broad spectrum of phytochemicals with antibiotic activity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest

et al. 2019

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“…Besides being used as food by poor people, it is also used in popular medicine as laxative, emollients, and to treat skin wounds and inflammation. 11,12 The use of plants for functional purposes in production of processed products can be a viable and easy option for prevention of diseases. The production of functional flours is useful since different products nutritionally enriched can be developed.…”

Section: Introductionmentioning

confidence: 99%

Pereskia aculeata Miller Flour: Metabolic Effects and Composition

Barbalho

Guiguer

Marinelli

et al. 2016

Journal of Medicinal Food

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Pereskia aculeata Miller is known in Brazil as ora-pro-nobis (OPN) and has been used commonly in the folklore medicine. The purpose of our study was to evaluate the composition and the effects of OPN flour on the metabolic profile and intestinal motility of Wistar rats. Animals were divided randomly into five groups (n = 10): G1 (control group) and G2 (treated with OPN flour). For the intestinal motility: G3 (control group), G4 (treated with senne), and G5 (treated with OPN flour). After 40 days, G1 and G2 were euthanized and metabolic profiles were analyzed (glycemia, cholesterol, triglycerides, high density lipoprotein [HDL-c], C reactive protein, AST, ALT, Lee Index, weight, and visceral fat). The flour of OPN was effective in reducing percentage of weight gain, visceral fat, levels of total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein, and increased HDL-c. Significance was also found in the distance covered by the activated charcoal from the pylorus to the beginning of the cecum, which was higher in animals treated with OPN. Our results indicate that OPN flour may bring health benefits, as the improvement of the intestinal motility, and it is associated with reduction of visceral fat and lipid profile, as well as the increase of HDL-c levels. With these results, we may suggest that the incorporation of this flour in different industrial products may be a convenient and effective way for the intake of healthier products.

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“…Ot is often referred to as "green meat" or "vegetable meat" due to its high protein content (Madeira et al, 2016). Research also indicates its leaves are an important source of fiber, calcium and iron Martin et al, 2017), bioactive compounds such as antioxidants and anti-inflammatory substances (Pinto et al, 2015). Encouragement of its use is seen as an important strategy to improve nutrition and income among poor people .…”

Section: Introductionmentioning

confidence: 99%

Exploring consumers’ knowledge and perceptions of unconventional food plants: case study of addition of Pereskia aculeata Miller to ice cream

et al. 2020

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Verdolaga contains high concentrations of omega-3, omega-6 and antioxidant compounds (Dliveira et al., 2009). Ot is used in folk medicine for its diuretic, anti-inflammatory and vermifuge effects (Albuquerque et al., 2007; Xiang et al., 2005). As a food, it can be consumed in salads, juices and stir-fries, imparting a mildly acidic flavor (Dliveira et al., 2009). Nasturtium is an ornamental, edible and medicinal plant. On cuisine, the flowers are used to decorate plates, especially salads, and have a spicy flavor (Mlcek & Rop, 2011). For medicinal use, it is considered an important source of carotenoids (Garzón & Wrolstad, 2009), and for having antibacterial, diuretic, expectorant and laxative activities (Mlcek & Rop, 2011). Air yam, as the name suggests, is a bulb that grows above ground. Ot is used in folk medicine to treat cancer and skin infections (Wang et al., 2012). On cuisine, it is used in baked goods and purees, to replace potato flour. Amaranth is a plant with many uses, of all parts. Ot is rich in iron, potassium, calcium, magnesium and vitamins (Jiménez-Aguilar & Grusak, 2017). Ot also has nutraceutical properties for the treatment of infections, hepatic problems, cancer and degenerative diseases (Peter & Gandhi, 2017). Taro is rich in fibers (0.6 to 0.8 g/100 g), proteins (2 to 6 g/100 g), carbohydrates (70-80 g/100 g) and vitamins (Kumar et al., 2017). As an important source of starch, it is employed to make four

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Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of acute and chronic dermatitis

Abstract: This study showed that the acute and chronic anti-inflammatory activity of P. aculeata leaves is very promising, and corroborates to better understand their ethnopharmacological applications.

Cited by 78 publications

References 49 publications

Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest

Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest

Pereskia aculeata Miller Flour: Metabolic Effects and Composition

Exploring consumers’ knowledge and perceptions of unconventional food plants: case study of addition of Pereskia aculeata Miller to ice cream

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