Perfil clínico e laboratorial de pacientes pediátricos e adolescentes com diabetes tipo 1

Jose, Laura Pereira da Silva; Cardoso-Demartini, Adriane; Liberatore, Raphael Del Roio; Paulino, Maria Fernanda Vanti Macedo; Lemos-Marini, Sofia Helena Valente de; Guerra‐Júnior, Gil; Rodrigues, Albertina Gomes

doi:10.1590/s0021-75572009000600004

Cited by 9 publications

(1 citation statement)

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“…It is also a known fact that T1D patients with improper body weight often do not have optimal glycemic control [ 24 , 25 ]. In our study, it is reflected by a positive correlation of BMI SDS and HbA1c.…”

Section: Discussionmentioning

confidence: 99%

Markers of Anemia in Children with Type 1 Diabetes

Rusak

Rotarska-Mizera

Adamczyk

et al. 2018

Journal of Diabetes Research

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Aim The aim of the study was to assess markers of anemia in type 1 diabetes (T1D) children, compare them to results obtained in the control group, and estimate their relation to BMI SDS. Methods 94 (59% ♀) T1D children without other autoimmune disorders, aged 12.5 ± 4.1 years, T1D duration: 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol). Sex- and age-matched controls (43 children). In all children, anthropometric measurements, the blood count, iron turnover parameters, and vitamin B12 concentration were taken. Results T1DM children had significantly higher red cell distribution width (RDW) (13.6 versus 12.6%; p < 0.001), hepcidin (0.25 versus 0.12 ng/ml; p < 0.001), and vitamin B12 concentrations (459 versus 397 pg/ml; p < 0.01) and lower TIBC (59.09 versus 68.15 μmol/l; p < 0.001) than in the control group. Logistic regression revealed that RDW, TIBC (both p < 0.001), and hepcidin (p < 0.05) significantly differentiated both groups. In T1DM children, BMI SDS negatively correlated with vitamin B12 (p < 0.01) concentration and mean corpuscular hemoglobin concentration (p < 0.05) and positively with TIBC (p < 0.01) and HbA1c (p < 0.001). Conclusions Patients and controls differed especially in terms of RDW and TIBC. In studied T1DM children, BMI SDS was associated to iron metabolism parameters and vitamin B12 concentration.

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Section: Discussionmentioning

confidence: 99%