Perfil clínico-epidemiológico de pacientes com neurocisticercose atendidos no Hospital Universitário Regional de Maringá, Paraná, Brasil

Benedeti, Márcia Regina; Falavigna, Dina Lúcia Morais; Falavigna-Guilherme, Ana Lúcia; Araújo, Silvana Márques de

doi:10.1590/s0004-282x2007000100025

Cited by 15 publications

(4 citation statements)

References 30 publications

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“…This supports prior reports suggesting that NCC may be more common in children in South Africa than elsewhere [52]. Gender-specific estimates could not be calculated, and we could not verify whether females are more affected by NCC, as has been previously hypothesized [50].…”

Section: Discussionsupporting

confidence: 77%

“…Although CT and MRI are considered the best tools to diagnose NCC, they can miss early stages of the larvae infestation in the brain [49]. The definitive diagnosis of NCC has to be made by a set of methods including neuro-imaging procedures, histological techniques and immunological investigations, because the use of any single method may provide flawed diagnoses [50]. As mentioned earlier, many neuro-imaging lesions are not pathognomonic of NCC [51].…”

Section: Discussionmentioning

confidence: 99%

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A Systematic Review of the Frequency of Neurocyticercosis with a Focus on People with Epilepsy

et al. 2010

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BackgroundThe objective of this study is to conduct a systematic review of studies reporting the frequency of neurocysticercosis (NCC) worldwide.Methods/Principal FindingsPubMed, Commonwealth Agricultural Bureau (CAB) abstracts and 23 international databases were systematically searched for articles published from January 1, 1990 to June 1, 2008. Articles were evaluated for inclusion by at least two researchers focusing on study design and methods. Data were extracted independently using standardized forms. A random-effects binomial model was used to estimate the proportion of NCC among people with epilepsy (PWE). Overall, 565 articles were retrieved and 290 (51%) selected for further analysis. After a second analytic phase, only 4.5% of articles, all of which used neuroimaging for the diagnosis of NCC, were reviewed. Only two studies, both from the US, estimated an incidence rate of NCC using hospital discharge data. The prevalence of NCC in a random sample of village residents was reported from one study where 9.1% of the population harboured brain lesions of NCC. The proportion of NCC among different study populations varied widely. However, the proportion of NCC in PWE was a lot more consistent. The pooled estimate for this population was 29.0% (95%CI: 22.9%–35.5%). These results were not sensitive to the inclusion or exclusion of any particular study.Conclusion/SignificanceOnly one study has estimated the prevalence of NCC in a random sample of all residents. Hence, the prevalence of NCC worldwide remains unknown. However, the pooled estimate for the proportion of NCC among PWE was very robust and could be used, in conjunction with estimates of the prevalence and incidence of epilepsy, to estimate this component of the burden of NCC in endemic areas. The previously recommended guidelines for the diagnostic process and for declaring NCC an international reportable disease would improve the knowledge on the global frequency of NCC.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Frequency of Neurocyticercosis with a Focus on People with Epilepsy

et al. 2010

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“…The cysticerci promote an influx of inflammatory cells that vary according to the encephalic location of the parasite and to the time of infection starting from the moment they penetrate into the central nervous system. When it reaches the ventricles, an obstruction of the cerebrospinal fluid may occur leading to hydrocephaly, intracranial hypertension, ventricular dilatation, headache, inflammatory reactions, epilepsy, cerebral vascular accident, and radicular compression, presenting or not fibrosis [4][5][6] .…”

Section: Demyelination In Experimental Intraventricular Neurocysticermentioning

confidence: 99%

Demyelination in experimental intraventricular neurocysticercosis

Moura

Milhomem

Lima

et al. 2020

Arq. Neuro-Psiquiatr.

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Neurocysticercosis (NCC) is classified as a neglected tropical disease, which affects mainly Latin America and Africa in spite of some reports in North America and Europe. NCC represents the cause of up to 30% of the reported cases of epilepsy in endemic countries. The NCC injuries present direct relation to the development stage, location, and number of parasites as well as to the host immune response. This study aimed the characterization of the inflammatory response and tissue injuries by means of the analyses of the periventricular and parenchymatous demyelination through the experimental intraventricular NCC infection. Therefore, BALB/c mice were submitted to experimental NCC inoculation with Taenia crassiceps cysticerci. Their brains were removed at 7, 30, 60, and 90 days after the inoculation (DAI), and analyzed after staining with hematoxylin and eosin (HE), Luxol Fast Blue, and Nissl. It was possible to observe ventriculomegaly, inflammatory infiltration composed by polymorphonuclear and mononuclear cells, and foamy macrophages. The presence of inflammatory cells was associated with neurodegeneration detected by the areas with demyelination observed initially in the periventricular area and lately in the parenchyma. In conclusion, the presence of cysticerci and the consequent inflammation were able to promote initial periventricular demyelination followed by parenchymatous demyelination as the infection progressed.

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“…Em países em desenvolvimento, a precariedade das condições de saneamento básico e o baixo nível sócio econômico cultural favorecem a disseminação da cisticercose humana (AGAPEJEV, 2003;COYLE et al, 2012). No continente americano a teníase e a cisticercose encontram-se endêmica na Bolívia, Colômbia, Equador, Guatemala, México, Peru e Brasil (ANTONIUK, 1999; LEITE, 2001;BRAGAZZA et al, 2002;AGAPEJEV, 2003;MENDES et al, 2005;BENEDETTI et al, 2007). Devido à falta de diagnóstico específico e de baixo custo, a ocorrência da NC tem sido considerada baixa na região Nordeste (PFUETZENREITER; ÁVILA- PIRES, 2000;AGAPEJEV, 2003;NASH, GARCIA, 2011;DEL BRUTTO, 2012a).…”

Section: Aspectos Epidemiológicos Do Complexo Teníase-cisticercoseunclassified

Frações antigênicas de metacestódeos de Taenia saginata na neurocisticercose humana: análise proteômica e aplicação em plataformas imunodiagnósticas

Nunes¹

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Agradecimentos A Deus, pelo dom da vida, por me proteger, colocar pessoas especiais em minha vida, e me dar força para vencer todos os obstáculos. À minha família, pelo incentivo que sempre me dão. À Universidade Federal de Uberlândia por todos os títulos concedidos, pela oportunidade de estudo gratuito e de qualidade. Em especial ao Programa de Pós-Graduação em Imunologia e Parasitologia Aplicadas, por todo aprendizado e pela minha formação. À Profa. Dra. Julia Maria Costa Cruz, pela orientação, oportunidade e dedicação. Muito obrigada pela confiança ao longo desses nove anos de Laboratório de Diagnóstico de Parasitoses, em especial pela autonomia que me concedeu durante a execução do trabalho. Serei eternamente grata por todos os ensinamentos e convivência! Sua equipe é especial, que possamos continuar a parceria! Ao Prof. Dr. Jair Pereira da Cunha Júnior pela coorientação, disponibilidade, conselhos e ideias compartilhadas. Muito obrigada pela parceria indispensável, a qual tornou nossos estudos possíveis. Ao Dr. Henrique Tomaz Gonzaga, além da participação na banca de defesa, pela amizade, auxílio técnico e metodológico, muito obrigada por todos os ensinamentos! Foi gratificante trabalhar e conviver com você ao longo desses anos, esse trabalho foi possível graças à sua ajuda! À Dra. Vanessa da Silva Ribeiro, por avaliar a tese na banca de defesa, além da disponibilidade sempre imediata. Obrigada pelos ensinamentos e convívio desde o início da minha vida profissional.

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Perfil clínico-epidemiológico de pacientes com neurocisticercose atendidos no Hospital Universitário Regional de Maringá, Paraná, Brasil

Cited by 15 publications

References 30 publications

A Systematic Review of the Frequency of Neurocyticercosis with a Focus on People with Epilepsy

A Systematic Review of the Frequency of Neurocyticercosis with a Focus on People with Epilepsy

Demyelination in experimental intraventricular neurocysticercosis

Frações antigênicas de metacestódeos de Taenia saginata na neurocisticercose humana: análise proteômica e aplicação em plataformas imunodiagnósticas

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