To evaluate the prevalence and cases of deaths from hepatitis B and C in the state of Mato Grosso between 2011 and 2020. This was an observational study of the ecological type with a quantitative and descriptive approach using secondary data obtained in health information systems from the state and municipalities of Mato Grosso between January 2011 and December 2020. Descriptive statistics and Pearson’s chi-square test were used, with a significance level of 5%. The study was approved by the Research Ethics Committee (CAAE: 19545619.1.0000.8088). A total of 6486 cases of hepatitis B, C and B+C were recorded, with 2012 being the year with the highest number of cases (12.47%) and 2020 the lowest (3.84%); there was a statistical significance between the number of cases of hepatitis in relation to the years. The prevalent etiological classification was hepatitis B (71.83%). Regarding deaths, there were 259 deaths, with the highest number recorded from 2014 to 2015 (12.74%) and 2011 the lowest number (5.02%). The category that caused the most deaths was chronic viral hepatitis, with more than half of the records (59.46%). There was statistical significance in the relationship between deaths and the years of study analyzed. This study showed that the results found are similar to other studies in other states and cities in Brazil that have a similar theme. Professionals and managers must take a critical look at prevention and health promotion actions for viral hepatitis B and C, primarily hepatitis B.