Perfil clínico y parasitológico de la malaria por Plasmodium falciparum y Plasmodium vivax no complicada en Córdoba, Colombia.

Knudson-Ospina, Angélica; Sánchez-Pedraza, Ricardo; Pérez-Mazorra, Manuel Alberto; Cortés-Cortés, Liliana Jazmín; Guerra-Vega, Ángela Patricia; Nicholls-Orejuela, Rubén Santiago

doi:10.15446/revfacmed.v63.n4.47953

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…In Colombia, there are no studies on the clinical characteristics of PAM to compare our results, but a study with 112 patients of the general population diagnosed with TBS presented a different clinical profile: 99% with fever, 94% sweating, and 94% musculoskeletal pain. Most of the signs and symptoms (diarrhea, listlessness, palmar pallor, dry mucous membranes) were statistically more frequent in P. falciparum, and only chills it was more frequent in P. vivax [23]; this is different from our results in pregnant women, which demonstrate that pregnancy generates changes in the clinical profile.…”

Section: Discussioncontrasting

confidence: 99%

Clinical and Parasitological Profiles of Gestational, Placental and Congenital Malaria in Northwestern Colombia

2023

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This study compared the clinical–parasitological profiles of gestational (GM), placental (PM), and congenital (CM) malaria in northwestern Colombia. A cross-sectional study with 829 pregnant women, 549 placentas, and 547 newborns was conducted. The frequency of GM was 35.8%, PM 20.9%, and CM 8.5%. P. vivax predominated in GM; in PM, the proportion of P. vivax and P. falciparum was similar; in CM, P. falciparum predominated. The main clinical findings were headache (49%), anemia (32%), fever (24%), and musculoskeletal pain (13%). The clinical manifestations were statistically higher in P. vivax infections. In submicroscopic GM (positive with qPCR and negative with thick blood smear), the frequency of anemia, sore throat, and a headache was statistically higher compared with pregnant women without malaria. GM, PM, and CM reduce birth weight and head circumference. In Colombia, this is the first research on the clinical characteristics of GM, PM, and CM; contrary to evidence from other countries, P. vivax and submicroscopic infections are associated with clinical outcomes.

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Section: Discussioncontrasting

confidence: 99%

Clinical and Parasitological Profiles of Gestational, Placental and Congenital Malaria in Northwestern Colombia

2023

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“…Malaria symptoms (fever, chills, and headache) [ 24 , 25 ] were common, and signs such as skin-mucosa pallor, jaundice, and choluria were present in all patients regardless of the parasitic species. However, in contrast with other studies reporting low back pain in 3.7% [ 26 ] or 13.3% [ 27 ] of cases, this symptom was observed in almost half of the patients evaluated in this study.…”

Section: Discussionmentioning

confidence: 99%

The clinical–epidemiological profile of malaria patients from Southern Venezuela, a critical hotspot in Latin America

Forero‐Peña¹,

Carrión‐Nessi

Chavero³

et al. 2021

Malar J

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Background Venezuela accounted for 55% of the cases and 73% of the malaria deaths in the Americas in 2019. Bolivar state, in the southeast, contributes > 60% of the country's Plasmodium vivax and Plasmodium falciparum cases every year. This study describes the clinical–epidemiological characteristics of clinical malaria patients in this high-transmission area. Methods A prospective study was conducted on patients seeking medical attention in three medical centres in the state capital, Ciudad Bolivar, between June and October 2018. Malaria diagnosis was carried out using microscopy following national standards. Malaria-positive patients were examined for clinical symptoms, and haematological tests were performed at the time of diagnosis. Patients were followed up by telephone to evaluate malaria recurrences. Results Out of 287 patients, 200 (69.7%) were positive for P. vivax, 69 (24%) for P. falciparum, and 18 (6.3%) had mixed (P. vivax/P. falciparum) infections. Patients' median age was 33 years (IQR 20), 168 (69%) were men, and 40% practiced gold mining as the main occupation. Fever (96.5%), chills (91.3%), and headaches (90.6%) were the most frequent symptoms. At least one symptom associated with severe malaria was observed in 69 out of 161 patients with complete clinical evaluation (42.9%). Plasmodium vivax infections were found in 42 out of 69 (60.9%) severe cases; by contrast, P. falciparum and mixed malaria caused 34.8% (24/69) and 4.4% (3/69) of infections, respectively. Two patients died of cerebral malaria. Mean hemoglobin was lower in the patients infected with P. falciparum than those infected with P. vivax. Regardless of the parasite causing the infection, patients presented high levels of total bilirubin, aminotransferases (AST, ALT), and lactate dehydrogenase (LDH). Out of the 142 patients followed up by phone for three months (49.5% of the 287 patients), 35 (24.7%) reported recurrences. Conclusions The high malaria prevalence among young male adults practicing gold mining suggests that this occupation is a significant risk factor. The unexpected high prevalence of P. vivax patients with at least one criteria of severe clinical disease is a matter of concern. Whether it is the result of a lack of timely diagnosis and effective treatment should be explored.

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Perfil clínico y parasitológico de la malaria por Plasmodium falciparum y Plasmodium vivax no complicada en Córdoba, Colombia.

Cited by 2 publications

References 15 publications

Clinical and Parasitological Profiles of Gestational, Placental and Congenital Malaria in Northwestern Colombia

Clinical and Parasitological Profiles of Gestational, Placental and Congenital Malaria in Northwestern Colombia

The clinical–epidemiological profile of malaria patients from Southern Venezuela, a critical hotspot in Latin America

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