Perfil de la viscosidad sanguínea en la hipoacusia rápidamente progresiva con Western-blot positivo

Callejo, Francisco Javier García; Vernetta, Carlos de Paula; Zamarreño, A. Platero; Alborch, M.H. Orts; Gil-Carcedo, Luis M.; Algarra, Jaime Marco; Vila, Manuel Mesa; Pérez, Constantino Morera

doi:10.1016/s0001-6519(06)78668-x

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…The predictive relevance of blood viscosity in the literature has been suspected to be intrinsically germane to many disease processes. Types of problems where blood viscosity appears to play some pathophysiologic role include immunologic diseases ( Gudmundsson et al, 1993 ), inflammatory diseases ( Nwose, 2010 ), hemolytic anemias ( Bowers et al, 2013 , 2018 ; Kucukal et al, 2020 ), hearing loss ( Hildesheimer et al, 1990 ; Garcia Callejo et al, 2006 ), diabetes ( Nakanishi et al, 2004 ; Richards and Nwose, 2010 ; Schiapaccassa et al, 2019 ), renal disorders ( Jung et al, 2017 ), sickle cell disease ( Klug et al, 1974 ), and cerebrovascular disease ( Song et al, 2017 ). However, the association between cardiovascular disease and blood viscosity has been looked at most extensively throughout the literature ( Lowe, 1992 ; Kenyeres et al, 2008 ; Chevalier et al, 2013 ; Buyan et al, 2017 ; Celik et al, 2017 ; Peters et al, 2017 ; Sloop et al, 2018 ; Cekirdekci and Bugan, 2020 ; Engin and Guvenc, 2020 ).…”

Section: Descriptions Of the Carotid Sinus Physiology Throughout Historymentioning

confidence: 99%

The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention

Iskander

Bilgi

Naftalovich

et al. 2021

Front. Bioeng. Biotechnol.

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The association between blood viscosity and pathological conditions involving a number of organ systems is well known. However, how the body measures and maintains appropriate blood viscosity is not well-described. The literature endorsing the function of the carotid sinus as a site of baroreception can be traced back to some of the earliest descriptions of digital pressure on the neck producing a drop in blood delivery to the brain. For the last 30 years, improved computational fluid dynamic (CFD) simulations of blood flow within the carotid sinus have demonstrated a more nuanced understanding of the changes in the region as it relates to changes in conventional metrics of cardiovascular function, including blood pressure. We suggest that the unique flow patterns within the carotid sinus may make it an ideal site to transduce flow data that can, in turn, enable real-time measurement of blood viscosity. The recent characterization of the PIEZO receptor family in the sinus vessel wall may provide a biological basis for this characterization. When coupled with other biomarkers of cardiovascular performance and descriptions of the blood rheology unique to the sinus region, this represents a novel venue for bioinspired design that may enable end-users to manipulate and optimize blood flow.

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