Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos

Abstract

Aim:The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, Study design: Historic cohort. Material and method: in the state of Sergipe, during the period 1980-1999. The neoplasms were individualized by gender, age, race of the patients, anatomic localization of the lesions and histopathological diagnosis. Results: Out of 162,312 registered cases, 245 were salivary gland epithelial neoplasms and 187 (76.33%) were benign and 58 (23.67%) were malignant. Pleomorphic adenoma was the most frequent benign neoplasm (89.94%) and adenoid cystic carcinoma represented the most prevalent malignant neoplasm (22.41%). The benign neoplasms occurred mainly between the second and third decades of life and showed preference for female, while malignant neoplasms were diagnosed between the sixth and seventh decades of life and in women. Conclusion: The data demonstrated that epidemiology profile of the studied neoplasms corroborated most of the studied literature.

A clinicopathological study on morphological pattern and management of parotid tumours: a multicentric experience

“…[6]. These tumours have infectious, granulomatous , auto-immune, obstructive, developmental, idiopathic and neoplastic etiology [7]. Most often they present as non-tender gradually progressive masses in respective regions.…”

An unusual pleomorphic adenoma

“…The diversity of histological aspects displayed by neoplasms of the salivary glands causes great difficulty in terms of universal classification [1][2] . Pleomorphic adenoma (PA) is the most commonly found neoplasm amongst tumors of the major and minor salivary glands, originally called a mixed benign tumor in 1866 [3][4][5] .…”

“…The presence of areas of necrosis, atypical mitoses, invasiveness and extensive hyalinization suggests the possibility of malignancy. On the other hand, calcifications inside the mass suggest a benign neoplasm or, less commonly, schwannoma or mucoepidermoid carcinoma 1,5,10,[13][14] . Even though it has well-known clinical and morphological characteristics, the malignancy of the pleomorphic adenoma is the holder of a pathogenesis which is still uncertain, as is the expression of oncogenes and the factors that influence its transformation 11 .…”

“…The removal of bone is not generally required as the pleomorphic adenoma does not invade the bone tissue, although it may cause resorption from pressure. Given correct surgical removal, the prognosis is excellent [1][2][3]6,10,15 . itself in other areas of the head and neck.…”

“…In the majority of cases it does not cause ulceration of the overlying mucosa 3 . The minor salivary glands, when affected, are normally located, in order of prevalence, at the junction of the hard and soft palates, lips, tongue, cheeks and floor of the mouth; the histological description in these cases is similar to that of adenomas of the major salivary glands 1,3,10,12 .…”