Perfil epidemiológico e genotípico da infecção pelo vírus da hepatite B no Norte de Portugal

Mota, Ana; Guedes, Fátima; Areias, Jorge; Pinho, Luciana; Cardoso, Margarida Fonseca

doi:10.1590/s0034-89102010000600014

Cited by 6 publications

(8 citation statements)

References 18 publications

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“…This rate is similar to the estimate of 75.0% vaccination coverage against hepatitis B among American hospital HWs. 18 The results also approach those observed among hospital workers (73.5%), 6 laboratory professionals (74.5%), 17 dentists (75.0%) 15 and workers who were victims of accidents with biological material (72.8%) in Brazil. 1 However, vaccinal coverage in some subgroups may reach lower frequencies, for example 64.6% among primary care HWs in Florianópolis, Santa Catarina 11 and 65.6% of the anesthesiologists in Goiânia, GO.…”

Section: Discussionsupporting

confidence: 73%

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Vacinação contra hepatite B e exposição ocupacional no setor saúde em Belo Horizonte, Minas Gerais

Assunção

Araújo

Ribeiro³

et al. 2012

Rev. Saúde Pública

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OBJECTIVE:To identify factors associated with vaccination against hepatitis B among healthcare workers. METHODS:This was a cross-sectional study on 1,808 public-sector healthcare workers in Belo Horizonte, Southeastern Brazil, in 2009. A self-administered questionnaire was used and the vaccination situation was analyzed taking sociodemographic characteristics, lifestyle and working conditions and characteristics into consideration. Univariate (p < 0.20) and multiple (p < 0.05) statistical analyses were performed using Poisson regression to evaluate factors associated with vaccination. RESULTS:Of the workers, 85.6% declared that they had been vaccinated, although only 74.9% of the vaccinated professionals had received a complete imunization schedule. Not having been vaccinated was associated with not having a partner; having high school, technical or incomplete higher education level; work characteristics such as working in surveillance or the administrative/ general services sector; and not using personal protection equipment. CONCLUSIONS:Groups with lower vaccination coverage were identifi ed. Efforts are required to ensure access and adherence to vaccination among healthcare workers, such as awareness-raising mechanisms.

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Section: Discussionsupporting

confidence: 73%

“…22 In Portugal, viral hepatitis is in second place among the causes of liver diseases. 15 The main groups at risk are healthcare workers (HWs), patients undergoing dialysis and newborns whose mothers are AgHBs carriers. The infectivity of HBV is 57 times greater than that of the human immunodefi ciency virus (HIV).…”

Section: Introductionmentioning

confidence: 99%

Vacinação contra hepatite B e exposição ocupacional no setor saúde em Belo Horizonte, Minas Gerais

Assunção

Araújo

Ribeiro³

et al. 2012

Rev. Saúde Pública

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“…genotype. Previous studies done in 2008-2009 and 2013-14 in the north or center of the country, with samples from prisoners, pregnant women, or blood donors reported genotype D as the most prevalent [18][19][20][21][22][23]. However, none of these studies used phylogenetic analysis to classify the HBV strains.…”

Section: Plos Onementioning

confidence: 99%

“…Genotype E was referred as more common in Central-Southern (10-62%) than in Northern Portugal (1-4%) [18][19][20][21][22]. Genotypes C and F have been reported in the North of the country on rare occasions [23]. In addition to this, previously unpublished data of a small patient population of Hospital Santa Maria in Lisbon indicated the circulation of minority genotypes such as B, C and F [24].…”

Section: Introductionmentioning

confidence: 99%

Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide

Marcelino

Ezeonwumelu

Janeiro³

et al. 2022

PLoS ONE

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In Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (n = 32, 24.6%). Spatio-temporal evolutionary dynamics was reconstructed in BEAST using a Bayesian Markov Chain Monte Carlo method, with a GTR nucleotide substitution model, an uncorrelated lognormal relaxed molecular clock model, a Bayesian skyline plot, and a continuous diffusion model. HBV subgenotype D4 was the first to be introduced in Portugal around 1857 (HPD 95% 1699–1931) followed by D3 and A2 a few decades later. HBV genotype E and subgenotype A1 were introduced in Portugal later, almost simultaneously. Our results indicate a very important role of Portugal in the exportation of subgenotypes D4 and A2 to Brazil and Cape Verde, respectively, in the beginning of the XX century. This work clarifies the epidemiological history of HBV in Portugal and provides new insights in the early and global epidemic history of this virus.

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“…Genotype E was referred as more common in Central-Southern (10-62%) than in Northern Portugal (1-4%) (9, 13). Genotypes C and F have been reported in the North of the country on rare occasions (14). In addition to this, previously unpublished data of a small patient population of Hospital Santa Maria in Lisbon indicated the circulation of minority genotypes such as B, C and F (15).…”

Section: Introductionmentioning

confidence: 99%

Phylogeography of hepatitis B: The role of Portugal in the early dissemination of HBV worldwide

Marcelino

Ezeonwumelu

Janeiro³

et al. 2022

Preprint

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In Portugal, the genetic diversity, origin of HBV, and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A (HBV/A) was the most prevalent (n=54, 41.5%), followed by D [HBV/D; (n=44, 33.8%)], and E [HBV/E; (n=32, 24.6%)]. Spatio-temporal evolutionary dynamics was reconstructed in BEAST using a Bayesian Markov Chain Monte Carlo method, with a GTR nucleotide substitution model, an uncorrelated lognormal relaxed molecular clock model, a Bayesian skyline plot, and a continuous diffusion model. HBV/D4 was the first subgenotype to be introduced in Portugal around 1857 (HPD 95% 1699-1931) followed by HBV/D3 and A2 a few decades later. HBV/E and HBV/A1 were introduced in Portugal later, almost simultaneously. Our results also indicate a very important role of Portugal in the exportation of HBV/D4 and A2 to Brazil and Cape Verde, respectively, at the beginning of the XX century. This work clarifies the epidemiological history of HBV in Portugal and shows that Portugal had an important role in the global spread of this virus.

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Perfil epidemiológico e genotípico da infecção pelo vírus da hepatite B no Norte de Portugal

Cited by 6 publications

References 18 publications

Vacinação contra hepatite B e exposição ocupacional no setor saúde em Belo Horizonte, Minas Gerais

Vacinação contra hepatite B e exposição ocupacional no setor saúde em Belo Horizonte, Minas Gerais

Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide

Phylogeography of hepatitis B: The role of Portugal in the early dissemination of HBV worldwide

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