Perfil funcional de pacientes portadores de seqüela de tuberculose de um hospital universitário

Abstract

Objective: To describe data related to the pulmonary function of patients with sequelae of pulmonary tuberculosis, pleural tuberculosis or both. Methods: In the outpatient clinic of a university hospital, 218 patients were evaluated. Of those 218, 56 had sequelae of tuberculosis (pulmonary, pleural or both), and 162 had other types of tuberculosis. All patients were evaluated in the pulmonary function laboratory between February 2000 and July 2004, and 43 were found to be eligible for inclusion in the study. Patients with a history of asthma, chronic pulmonary obstructive disease, cardiac insufficiency, collagen diseases, silicosis or thoracic surgery, as well as those for whom spirometry yielded unacceptable results or was not performed, were excluded. The lung fields were divided into six zones, and radiographic results were classified by degree: Ι (involvement of only one zone with no cavitation); ΙΙ (involvement of two or three zones or of one zone with cavitation); or ΙΙΙ (extensive involvement of three or more zones with or without cavitation). Results: The final study sample comprised 50 patients, 44 (88%) of whom had pulmonary tuberculosis. The most prevalent form (17/50; 34%) was mixed ventilatory disturbance. Severe disturbances were more significant in degree ΙΙΙ radiographs (p = 0.0002) and normal pulmonary function was predominant among patients presenting degree Ι and ΙΙ radiographs (p = 0.002). Conclusion:The early discovery and treatment of tuberculosis contribute to reduce the number of cases, as well as the incidence of tuberculosis sequelae, thereby improving the quality of life of tuberculosis patients. Further studies, involving longitudinal, sequential analysis and larger samples of patients with tuberculosis sequelae, should be conducted in referral centers in Brazil.

A Novel Scoring System to Measure Radiographic Abnormalities and Related Spirometric Values in Cured Pulmonary Tuberculosis

“…Among the patients with spirometric impairment, an obstructive pattern was the most prevalent, as observed in 57.69% (n =30/52) of cases, followed by a restrictive pattern in 42.30% (n = 22/52) of cases. This contrasts with another study, in which mixed ventilatory disorder was the most prevalent (34%), followed by obstructive (24%) and restrictive (18%) patterns, and in which only 24% of the sample showed a normal spirometry pattern [24]. …”

A Systematic Review of the Association between Pulmonary Tuberculosis and the Development of Chronic Airflow Obstruction in Adults

“…Some 40 years later, Ramos et al [14] published a cross-sectional study of 50 patients attending a tertiary referral clinic, who had completed TB treatment. Although 54% were never-smokers, they found AFO in 24% of subjects and mixed obstruction/restriction in a further 34%.…”

Trends and predictors of changes in pulmonary function after treatment for pulmonary tuberculosis

“…The histopathological abnormalities after treatment for pulmonary TB include fibrosis, bronchiectasis, and brochial stenosis, all of which can cause pulmonary function abnormalities 2–3. Previous studies have evaluated the changes in pulmonary function before, during and after pulmonary TB treatment 4–17. Between 48.7% and 76% of patients had pulmonary function abnormalities after completing pulmonary TB treatment 9–10,13–15,17.…”