Perfil ingestivo salino y presión arterial en la fibrosis quística

Martín, Saturnino; Martín, Juan José Díaz; Méndez, Carmen Perillán; Luis, Juan Argüelles; Vázquez, M. Vijande; Guerrero, Serafín Málaga

doi:10.1016/j.anpedi.2009.01.005

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Clinically, however, hypertension is an atypical symptom and not considered an important problem in CF patients [21] . Conversely, most of CF patients display lower or normal BP [5] . There are several explanations for the absence of elevated BP phenotype in CF patients.…”

Section: Discussionmentioning

confidence: 96%

CFTR plays an important role in the regulation of vascular resistance and high-fructose/salt-diet induced hypertension in mice

Zhang

Yuan

et al. 2021

Journal of Cystic Fibrosis

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Background:The pathophysiological roles of cystic fibrosis transmembrane-conductance regulator (CFTR) Cl − channels in the regulation of blood pressure (BP) remain controversial. Here we studied the function of CFTR Cl − channels in regulation of BP and in the high-fructose-salt-diet (HFSD) induced hypertension in mice. Methods:The systolic, diastolic and mean BP (SBP, DBP and MBP, respectively) were continuously monitored from unrestricted conscious wild-type ( cf tr + / + ) FVB and CFTR -knockout ( cf tr −/ − ) mice (8-week old, male). HFSD (64.7% fructose, 2% NaCl water) or control normal starch diet (CNSD, 58.9% corn starch, 0 NaCl water) was given for 8 weeks and vascular Doppler were performed. Real-time PCR and Western blot were used to examine mRNA and protein expression, respectively. Results:The aortic stiffness, daytime and nighttime SBP, DBP, and MBP of the cftr −/ − mice were significantly higher than those in the age-and gender-matched cftr + / + mice, which is consistent with the findings of increased vascular resistance in cystic fibrosis patients. The aortic stiffness, daytime and nighttime SBP, DBP, and MBP of cftr + / + mice fed with HFSD were all significantly higher than those fed with CNSD. Importantly, HFSD caused a significant decrease in mRNA and protein expression of WINK1, WINK4 and CFTR in aorta and mesenteric arteries , but not in the kidney, corroborating that HSFD-induced downregulation of WINKs and loss of CFTR function specifically in the arteries may mediate the increased BP.Conclusions: CFTR regulates peripheral arterial resistance and BP in vivo . HFSD-induced CFTR downregulation specifically in the arteries may be a novel mechanism for hypertension.

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Section: Discussionmentioning

confidence: 96%

CFTR plays an important role in the regulation of vascular resistance and high-fructose/salt-diet induced hypertension in mice

Zhang

Yuan

et al. 2021

Journal of Cystic Fibrosis

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Subclinical vascular, hemodynamic and arterial stiffness changes in adults with cystic fibrosis: cross-sectional observational study

Pessoa,

Velloso,

Inácio

et al. 2024

Sci Rep

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Cardiovascular diseases can be an emerging complication in cystic fibrosis (CF), as the median life expectancy has improved considerably. The objective of this study was to compare vascular, hemodynamic parameters and arterial stiffness in adult CF patients with healthy participants pared by sex and age, and to assess the factors associated with arterial stiffness in the CF group. This is a cross-sectional observational study. The evaluation of cardiovascular parameters was performed non-invasively using Mobil-O-Graph. 36 individuals with CF and 35 controls were evaluated. The mean arterial pressure (96.71 ± 10.98 versus 88.61 ± 7.40 mmHg, p = 0.0005), cardiac output (4.86 ± 0.57 versus 4.48 ± 0.44 L/min, p = 0.002) and systolic volume (64.30 ± 11.91 versus 49.02 ± 9.31 ml, p < 0.0001) were significantly lower in the CF group. The heart rate was higher in the CF when compared to the control (77.18 ± 10.47 versus 93.56 ± 14.57 bpm, p < 0.0001). The augmentation index (AIx@75) was higher in the CF than control (29.94 ± 9.37 versus 16.52 ± 7.179%, p < 0.0001). In the multivariate model controlled by body mass index and Forced Expiratory Volume in the first second, central systolic blood pressure and reflection coefficient directly related to AIx@75. Negatively related to AIx@75 were age and systolic volume. The adjusted determination coefficient was 87.40%. Individuals with CF presented lower arterial blood pressures and changes in cardiac function with lower stroke volume and cardiac output. The AIx@75, an indirect index of arterial stiffness and direct index of left ventricular overload, is increased in this population. The subclinical findings suggest the need for earlier cardiovascular assessment in this population due to increased risks of cardiovascular disease.

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Perfil ingestivo salino y presión arterial en la fibrosis quística

Cited by 2 publications

References 22 publications

CFTR plays an important role in the regulation of vascular resistance and high-fructose/salt-diet induced hypertension in mice

CFTR plays an important role in the regulation of vascular resistance and high-fructose/salt-diet induced hypertension in mice

Subclinical vascular, hemodynamic and arterial stiffness changes in adults with cystic fibrosis: cross-sectional observational study

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