Perfil lipídico residual en la cardiopatía isquémica recurrente

Millán, Jesús; Pedro‐Botet, Juan; Muñoz, A.; Corbella, Emili; Mangas, Alipio; Zúñiga, Manuel; Hernández‐Mijares, Antonio; Pintó, Xavier

doi:10.1016/j.medcli.2011.01.010

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…The present study reports an HR of 2.12 in the multiple model, the only variable that showed increased risk over time. A Spanish cohort presented results indicating a higher risk of recurrence in patients with lower LDL compared to patients who experienced a MACE for the first time (110.12 mg/dl vs. 131.6 mg/dl, p<0.01, respectively) [ 30 ]. However, despite analyzing this variable across multiple strata, only the threshold level of 120 mg/dL was found to be significant in the models.…”

Section: Discussionmentioning

confidence: 99%

Time-Dependent Risk for Recurrence in Survivors of Major Adverse Cardiovascular Events

Bermon,

Trejo-Valdivia,

Molina Castaño

et al. 2024

Cureus

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Introduction: The prevalence of the population with a history of an occlusive cardiovascular event has been increasing in recent years, which means that a large number of patients will have a higher risk of presenting a fatal recurrence. The aim is to determine variables associated with time-to-recurrent cardiovascular events and analyze how changes in low-density lipoprotein cholesterol (LDL-C) levels during follow-up may be associated with this time-to-event.Materials and methods: This is a prospective observational cohort study of 727 adults with a history of at least one occlusive cardiovascular event recruited at a referral hospital in northeastern Colombia. Data from a follow-up period of a maximum of 33 months (median 26 months) (one death) were used to define how clinical and sociodemographic variables impact the recurrence of major adverse cardiovascular events (MACE). Analyses were performed based on proportional hazard models and time-dependent hazard models.Results: Upon enrollment, 215 (30%) of the participants reported experiencing their most recent cardiovascular event within the preceding year. After two years, the recurrence rate was 12.38% (90/727). The risk of recurrence before two years was 3.9% (95% CI 2.7-5.6). In the multiple models, the presence of severe depression gives a Hazard Ratio of 8.25 (95% CI 2.98-22.86) and LDL ≥120 md/dl Hazard Ratio of 2.12 (95% CI 1.2 -3.9). It was found that LDL >120 mg/dl maintained over time increases the chances of recurrence by 1.7% (Hazard Ratio: 1.017, 95% CI 0.008-0.025).Conclusions: The present study allows us to identify a profile of patients who should be treated promptly in an interdisciplinary manner to avoid recurrences of coronary events.

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Section: Discussionmentioning

confidence: 99%

Time-Dependent Risk for Recurrence in Survivors of Major Adverse Cardiovascular Events

Bermon,

Trejo-Valdivia,

Molina Castaño

et al. 2024

Cureus

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Prevalence, Treatment, and Control of Hypercholesterolemia in High Cardiovascular Risk Patients: Evidences from a Systematic Literature Review in Spain

et al. 2015

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IntroductionCardiovascular diseases (CVDs) represent a major Public Health burden. High serum cholesterol levels have been linked to major CV risk. The objectives of this study were to review the epidemiology of hypercholesterolemia in high risk CV patients from Spain, by assessing its prevalence, the proportion of diagnosed patients undergoing pharmacological treatment and the degree of attained lipid control.MethodsA systematic literature review was carried out using Medline and two Spanish databases. Manuscripts containing information on hypercholesterolemia in several high CV risk groups [diabetes mellitus (DM), Systematic COronary Risk Evaluation (SCORE) risk >5, or documented CVD], published between January 2010 and October 2014, were included.ResultsOf the 1947 published references initially retrieved, a full-text review was done on 264 manuscripts and 120 were finally included. Prevalence of hypercholesterolemia ranged from 50 to 84% in diabetics, 30–60% in patients with DM or elevated SCORE risk, 64–74% with coronary heart disease, 40–70% in stroke patients, and 60–80% in those with peripheral artery disease. Despite the finding that most of them were on pharmacological treatment, acceptable control of serum lipids was very variable, ranging from 15% to 65%. Among those with heterozygous familial hypercholesterolemia, 95–100% received treatment but less than 50% achieved their therapeutic goals.ConclusionsAn elevated prevalence of hypercholesterolemia can be found in targeted groups at high CV risk. Although most patients are receiving pharmacological treatment, rates of lipid control continue to be low, both in primary and secondary prevention.Electronic supplementary materialThe online version of this article (doi:10.1007/s12325-015-0252-y) contains supplementary material, which is available to authorized users.

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Perfil lipídico residual en la cardiopatía isquémica recurrente

Cited by 2 publications

References 20 publications

Time-Dependent Risk for Recurrence in Survivors of Major Adverse Cardiovascular Events

Time-Dependent Risk for Recurrence in Survivors of Major Adverse Cardiovascular Events

Prevalence, Treatment, and Control of Hypercholesterolemia in High Cardiovascular Risk Patients: Evidences from a Systematic Literature Review in Spain

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